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Indian Journal of Medical and Paediatric Oncology
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Year : 1996  |  Volume : 17  |  Issue : 3  |  Page : 126-133

Gestational trophoblastic diseases.


Dept of Clinical Oncology, Weston Park Hospital, England

Correspondence Address:
PM Fisher
Dept of Clinical Oncology, Weston Park Hospital, England

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Source of Support: None, Conflict of Interest: None


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The gestational trophoblastic diseases, including complete and partial hydatidiform mole, choriocarcinoma and placental site tumour, are uncommon complications of pregnancy. Increasing maternal age and a previous molar pregnancy are the two main risk factors for development of these rare conditions. Abnormal vaginal bleeding is the usual means of presentation but upto a third of patients with choriocarcinoma first present with widely disseminated disease. Human chorionic gonadotrophin plays an important role as a tumour maker, with elevated levels confirming the diagnosis and also providing a valuable method of monitoring response to treatment. The majority of patients require no further treatment following termination of pregnancy, with less than 10 patients registered in the United Kingdom proceeding to chemotherapy. The most appropriate chemotherapeutic regimen is chosen by assessing the patients. It is essential that a specialist team is involved from the outset in order to prevent unnecessary complications and to identifiy those patients that require a change in treatment strategy at an early stage.


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