R Shreejith Department of Paediatric Oncology, Regional Cancer Centre, Trivandrum
Source of Support: None, Conflict of Interest: None
The occurrence of a second malignancy is one of the most devastating late effect of chemotherapy often associated with a high rate of morbidity and mortality. Cumulative probability has been estimated to be about 3-12 percent. Both radiotherapy and chemotherapy have been implicated in the development of second malignancies. Alkylating agents are associated with the highest risk. We report here a case of ANLL developing 4 years after treatment for Stage II-B (INSS) neuroblastoma.