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Indian Journal of Medical and Paediatric Oncology
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ORIGINAL ARTICLE
Year : 2009  |  Volume : 30  |  Issue : 1  |  Page : 20-23

Primary pancreatic lymphoma: Report of three cases with review of literature


1 Department of Surgical Oncology, Amrita Institute of Medical Sciences and Research Center, Ernakulam, Kerala, India
2 Department of Medical Oncology, Amrita Institute of Medical Sciences and Research Center, Ernakulam, Kerala, India
3 Department of Radiation Oncology, Amrita Institute of Medical Sciences and Research Center, Ernakulam, Kerala, India

Correspondence Address:
Altaf Gauhar Haji
Department of Surgical Oncology, Amrita Institute of Medical Sciences and Research Center, Ernakulam - 682 026, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5851.56331

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Background: Primary pancreatic lymphoma (PPL) is an extremely rare neoplasm, which may be confused with pancreatic adenocarcinoma. So far only about 150 cases of PPL have been reported. Materials and Methods: We present our experience of 3 cases of PPL over a 4-year period. Results: All the patients presented with vague abdominal pain of duration ranging from 1½ months to 3 months. Two patients had diagnosis confirmed histologically by CT-guided core biopsy or Fine needle aspiration procedure. We were able to avoid unnecessary laparotomy in 2 patients using preoperative guided Fine needle aspiration Cytology, although the third patient did undergo a Whipple's procedure as the diagnosis of PPL was not considered during the initial workup. Conclusions: There is no significant difference noted with regard to patient's age or duration of symptoms between patients with either pancreatic adenocarcinoma or PPL. The differential diagnosis of PPL includes pancreatic adenocarcinoma and secondary involvement of pancreas from extra-nodal lymphoma. Combination of two things is suggestive of Pancreatic lymphoma: (1) Bulky localized tumor in pancreatic head (2) Absence of significant dilatation of main pancreatic duct strengthens a diagnosis of pancreatic lymphoma over adenocarcinoma. Majority of patients can be managed with chemotherapy with much better prognosis compared to patients with pancreatic adenocarcinoma. Larger series of patients are needed to evaluate whether chemotherapy, eventually followed by involved-field radiation therapy, is the treatment of choice for PPL.


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