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Indian Journal of Medical and Paediatric Oncology
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Year : 2010  |  Volume : 31  |  Issue : 1  |  Page : 33-35

Secondary acute myeloid leukemia after successful treatment for osteosarcoma

1 Unit of Pediatric Oncology, Department of Medical Oncology, Kuwait Cancer Control Centre, Kuwait
2 Unit of Pediatric Oncology, Department of Hematology, Kuwait Cancer Control Centre, Kuwait

Correspondence Address:
Rakesh Mittal
Unit of Pediatric Oncology, Department of Medical Oncology, Post Box - 42262, Shuwaikh 70653
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-5851.68852

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Secondary acute myeloid leukemia (sAML) is a rare complication following chemotherapy for osteogenic sarcoma. However, the exact offending drug is difficult to prove as there is no consistent data. It usually develops 2 years after completion of therapy. We report a case of sAML that developed within 8 months of completing the treatment. The patient was treated with cisplatin, doxorubicin and high-dose methotreaxate followed by surgery (amputation). Eight months after completion of therapy, while on follow-up, he presented with leukocytosis and thrombocytopenia and confirmed to have AML.

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