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Indian Journal of Medical and Paediatric Oncology
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CASE REPORT
Year : 2010  |  Volume : 31  |  Issue : 3  |  Page : 96-100

Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? - A case report with review of literature


1 Department of Laboratory Medicine, Indo-American Cancer Institute and Research Centre, Hyderabad, India
2 Department of Medical Oncology, Indo-American Cancer Institute and Research Centre, Hyderabad, India
3 Cytogenetics and Molecular Biology, Gene Lab, Nanpura, Surat - 395 001, India

Correspondence Address:
Manu Goyal
Department of Laboratory Medicine, Indo-American Cancer Institute and Research Centre, Road No.14, Banjara Hills, Hyderabad
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5851.73603

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Primary plasma cell leukemia is a rare form of plasma cell dyscrasia. We present a case which had leukocytosis with numerous circulating plasma cells in the peripheral blood. Flow cytometry revealed an unusual CD117 expression. Free light chain analysis in the serum showed a markedly elevated level of free lambda light chains. Radiography did not reveal any lytic lesions. Fluorescent in-situ hybridization analysis revealed deletion of 13q14.3 and t(4;14)/t(11;14), while the cytogenetic analysis was normal. The patient was given chemotherapy and was subjected to autologous stem cell transplant, after which she is in complete remission till date.


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