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Indian Journal of Medical and Paediatric Oncology
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ORIGINAL ARTICLE
Year : 2011  |  Volume : 32  |  Issue : 2  |  Page : 92-95

Primary pediatric gastrointestinal lymphoma


1 Department of Pathology, Burdwan Medical College, Kolkata, India
2 Department of Pathology,Medical College, Kolkata, India
3 Institute of Postgraduate Medical Education & Research, Kolkata, West Bengal, India

Correspondence Address:
Ranjana Bandyopadhyay
1B/3, Uttarpara Housing Estate, 88 B, G T Road, P.O. Bhadrakali, Dist. Hooghly, Pin - 712 232, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5851.89786

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Background: Primary non-Hodgkin's lymphoma (NHL) of the gastrointestinal (GI) tract is the most common extranodal lymphoma in pediatric age group. Yet, the overall incidence is very low. The rarity of the disease as well as variable clinical presentation prevents early detection when the possibility of cure exists. Materials and Methods: We studied six cases of primary GI NHL in pediatric age group with reference to their clinical presentation, anatomic distribution and histopathologic characteristics. Results: All were males except one. Intestinal obstruction was the presenting feature in 50%. Half the cases showed ileocaecal involvement, while large bowel was involved in 16%. Histology showed four cases of diffuse large B-cell lymphoma (DLBCL), one case of Burkitt lymphoma, and one Burkitt-like lymphoma. Immunohistochemistry for Tdt, CD20, CD3, CD30, bcl2, bcl6 confirmed the morphological diagnosis. Conclusion: Pediatric GI lymphoma commonly involves the ileocaecal region and presents with intestinal obstruction. A higher prevalence of DLBCL is found compared to other series. A high proliferative index is useful in differentiating Burkitt-like lymphoma from DLBCL.


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