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Indian Journal of Medical and Paediatric Oncology
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ORIGINAL ARTICLE
Year : 2013  |  Volume : 34  |  Issue : 4  |  Page : 280-282

Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India


1 Department of Medical Oncology, Netaji Subhas Chandra Bose Cancer Research Institute, Kolkata, West Bengal, India
2 Department of Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute, Kolkata, West Bengal, India
3 Department of Molecular Pathology, Netaji Subhas Chandra Bose Cancer Research Institute, Kolkata, West Bengal, India

Correspondence Address:
Ashis Mukhopadhyay
Department of Medical Oncology, Netaji Subhas Chandra Bose Cancer Research Institute, 16A, Park Lane, Kolkata - 700 016, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-5851.125245

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Objective: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment. Materials and Methods: A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study. Results: Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients. Conclusions: We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome.


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