|IMAGES IN ONCOLOGY
|Year : 2013 | Volume
| Issue : 4 | Page : 334
Flagellate erythema induced by bleomycin toxicity
L Appaji1, C Vasu Reddy2, BS Aruna Kumari1, M Padma1
1 Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India
2 Department of Surgical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India
|Date of Web Publication||18-Jan-2014|
Department of Paediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka
Source of Support: None, Conflict of Interest: None
Bleomycin is a chemotherapeutic antibiotic used in various malignancies. Its toxicity is mainly lung and skin with marrow sparing effect. Here we would like to describe a characteristic skin reaction developed because of bleomycin in a case of intracranial germ cell tumor. Flagellate erythema which is a self-limiting toxic reaction can cause residual hyperpigmentation.
Keywords: Bleomycin, flagellate erythema, hyperpigmentation, skin toxicity
|How to cite this article:|
Appaji L, Reddy C V, Aruna Kumari B S, Padma M. Flagellate erythema induced by bleomycin toxicity. Indian J Med Paediatr Oncol 2013;34:334
|How to cite this URL:|
Appaji L, Reddy C V, Aruna Kumari B S, Padma M. Flagellate erythema induced by bleomycin toxicity. Indian J Med Paediatr Oncol [serial online] 2013 [cited 2020 Feb 18];34:334. Available from: http://www.ijmpo.org/text.asp?2013/34/4/334/125265
| Case|| |
A 15-year-old boy diagnosed as intracranial germ cell tumor underwent surgery, followed by cranial radiotherapy (45 Gy) and later treated with Bleomycin, Etoposide and Cisplatin(BEP) regimen. After third cycle of chemotherapy, he developed asymptomatic erythematous rashes over the back, chest and thighs, which later subsided with persistence of hyperpigmentation [Figure 1].
|Figure 1: Hyperpigmentation of flagellate erythematous rash over the back and thigh|
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Bleomycin is a chemotherapeutic antibiotic associated with various skin related toxicities such as Raynaud's phenomenon, flagellate erythema, and sclerodermoid reaction. In the acute stage they are erythematous rashes later may persist as hyperpigmentation marks.  Other conditions which may be associated with flagellate erythema are docetaxel, adult Still's disease, dermatomyositis and ingestion of shiitake mushrooms.  During the acute phase, topical with or without oral steroids may reduce symptoms.
| References|| |
|1.||Mowad CM, Nguyen TV, Elenitsas R et al. Bleomycin-induced flagellate dermatitis: A clinical and histopathological review. Br J Derm 1994;131:700-2. |
|2.||AJ Fyfe, P McKay. Toxicities associated with bleomycin. J R Coll Physicians Edinb 2010;40:213-5. |