Home | About IJMPO | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Indian Journal of Medical and Paediatric Oncology
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2017  |  Volume : 38  |  Issue : 3  |  Page : 321-325

Assessment of angiogenesis in children with acute lymphoblastic leukemia based on serum vascular endothelial growth factor assay


Department of Paediatric Oncology, Haematology and Chemotherapy, Upper Silesian Children's Healthcare Centre, Medical University of Silesia, Katowice, Poland

Correspondence Address:
Agnieszka Mizia-Malarz
Department of Paediatric Oncology, Haematology and Chemotherapy, Upper Silesian Children's Healthcare Centre, Medical University of Silesia, Medykow 1, 40-752 Katowice
Poland
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmpo.ijmpo_109_17

Rights and Permissions

Introduction: Vascular endothelial growth factor A (VEGFA) is a key proangiogenic cytokine. The role of angiogenesis in acute lymphoblastic leukemia (ALL) is still unclear. The purpose of the study was to assess angiogenesis in children with ALL based on serum VEGFA level determined at diagnosis and at remission with further participant subdivision into different risk groups. Materials and Methods: Forty children, aged 3–12 years (mean age: 8 years) with newly diagnosed ALL, were enrolled in the study. The control group (Group C) was twenty healthy children. According to the risk assessment, they were classified into a standard-risk group, an intermediate-risk group (IRG), or a high-risk group (HRG). Results: The median serum VEGFA levels at diagnosis were significantly higher in IRG and HRG as compared to Group C. The VEGFA levels at remission were significantly higher in all study groups, as compared to Group C. The differences in median values of serum VEGFA levels between the study groups both at diagnosis and at remission were not statistically significant. Conclusions: The angiogenesis in ALL seems to be intensified at diagnosis as a result of neoplasmatic bone marrow rebuilding and at remission as its intensive recovering.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed757    
    Printed1    
    Emailed0    
    PDF Downloaded72    
    Comments [Add]    

Recommend this journal