Home | About IJMPO | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Indian Journal of Medical and Paediatric Oncology
Search Article 
  
Advanced search 
 

 Table of Contents      
ORIGINAL ARTICLE
Year : 2018  |  Volume : 39  |  Issue : 2  |  Page : 184-187  

Bowel lymphoma in children: Management and outcome


1 Department of Paediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
2 Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
3 Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Date of Web Publication21-Mar-2018

Correspondence Address:
Dr. G Krishna Kumar
Department of Paediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry - 605 006
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmpo.ijmpo_94_17

Rights and Permissions
  Abstract 

Background: Primary bowel lymphoma is an uncommon neoplasm in children and not well documented in literature with regard to its outcome and management. Materials and Methods: A case record review of children with bowel lymphoma was undertaken in a tertiary care institute, from 2010 to 2016 and the relevant data were recorded. Results: 21 children were managed with bowel lymphoma over a period of 7 years. Pain abdomen was the most common presenting symptom (19/21). Ileum was the site of involvement in most children (17/21). Localised disease was seen in 13/21 while 8 had diffuse involvement. Predominantly (13/21) children presented at an advanced stage (III/IV). Surgical intervention was needed in 14/21 while 7/21 were managed only with chemotherapy. Majority (15/21) had Burkitt's lymphoma on histology. 13 of 21 (61.9%) have completed chemotherapy and on regular follow up. Among 8 who died, 6 were directly related to disease progression despite aggressive management. Conclusion: Bowel lymphoma in children is distinctly different in the site of presentation from that of the adults. Advanced stage at presentation portends poor prognosis. Bowel lymphoma is to be considered in case of recurrent intussusception in children.

Keywords: Bowel lymphoma, Burkitt's lymphoma, childhood malignancies, non-Hodgkin's lymphoma


How to cite this article:
Veerabhadra R, Kumar G K, Bibekanand J, Kumar N B, Kumaravel S, Bhawana B, Biswajit D. Bowel lymphoma in children: Management and outcome. Indian J Med Paediatr Oncol 2018;39:184-7

How to cite this URL:
Veerabhadra R, Kumar G K, Bibekanand J, Kumar N B, Kumaravel S, Bhawana B, Biswajit D. Bowel lymphoma in children: Management and outcome. Indian J Med Paediatr Oncol [serial online] 2018 [cited 2019 May 20];39:184-7. Available from: http://www.ijmpo.org/text.asp?2018/39/2/184/228111




  Introduction Top


The pediatric population constitutes 32.4% of the total population of India and malignancy is an emerging major childhood killer.[1] Primary tumors of the gastrointestinal (GI) tract are rare in children and represent <5% of all pediatric neoplasms.[2] The scarcity of the disease and variable clinical presentation preclude early diagnosis when the likelihood of cure exists.

Among GI malignancies, non-Hodgkin's lymphoma (NHL), especially Burkitt's lymphoma (BL) is the predominant variety.[3] In children, Paediatric gastrointestinal tract lymphoma (PGTLs) tend to occur in the small and large intestines, as opposed to the stomach in adults.[3]

Although lymphoma is the most common pediatric GI malignancy, there are not many studies available in the literature. The study documents the experience of pediatric bowel lymphomas in a tertiary care institute.

Objective

  1. To evaluate the clinical presentation of pediatric GI lymphoma
  2. To determine the prognosis and prognostic factors of pediatric GI lymphoma.



  Materials and Methods Top


It is a retrospective plus prospective study of GI lymphomas in pediatric age group presented to Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, over a period of 7 years (2010–2016). Patient demography, history, examination, investigations, treatment, and follow-up were recorded.

Dawson et al.'s [4] criteria were used to differentiate primary from secondary bowel lymphoma. The tumor was considered primary when there is no superficial adenopathy at diagnosis, no mediastinal adenopathy at chest radiography, normal blood cell counts, no involvement of liver and spleen, and involvement of only regional lymph nodes at laparotomy.

St Jude's Staging system [5] was used to stage the disease.

Investigations to complete the workup included ultrasonogram, computed tomography [Figure 1], biopsy of mass, bone scan, and bone marrow biopsy.
Figure 1: CECT Abdomen showing a small bowel mass

Click here to view


LMB-96 chemotherapy protocol [Figure 2] was used for treating patients. Progressive disease patients received additional rituximab, ifosfamide, carboplatin, etoposide regimen. Surgery was reserved for residual tumor and complications of mass.
Figure 2: LMB-96 chemotherapy protocol

Click here to view


Numerical data were expressed in mean ± standard deviation and range. Fisher's exact t-test was used to find a difference between two groups and Chi-square test was used to find a difference between three or more groups. P < 0.05 was considered statistically significant.


  Results Top


A total of 21 patients were found during the study period. Mean age was 6.05 ± 3.34 years with 14 (66.67%) patients aged ≤5 years. The smallest patient was aged 3 years while the eldest was 14 years. Males were more commonly affected (7:1). Pain abdomen was the most common presentation (90.5%), followed by distension of abdomen (85.7%) [Table 1].
Table 1: Clinical presentation of pediatric gastrointestinal lymphoma

Click here to view


In the study, 7 (33.3%) patients presented with radiological intussusception while 2 (9.5%) had actual intussusception [Figure 3] whereas 4 (19%) patients had target sign on imaging suggestive of intussusception. One (4.7%) patient had a history of surgery for intussusception.
Figure 3: Lymphoma presenting as intussusception

Click here to view


Most common site of involvement was terminal ileum (81%) [Table 2]. Thirteen (61.9%) patients had localized disease while 8 (38.1%) patients had diffuse disease at presentation. Eight (38.1%) cases belonged to Stage II of St. Jude's system of classification, 7 (33.3%) belonged to Stage III, and 6 (28.6%) belonged to Stage IV. Eighteen (85.7%) patients had primary GI lymphoma whereas 3 (14.3%) had secondary GI lymphoma.
Table 2: Site of involvement

Click here to view


Seven (33.3%) patients were managed with chemotherapy alone while 14 (66.7%) required some surgical intervention at least. Surgical intervention included resection and anastomosis (9 patients - 42.9%) [Figure 4], diversion (3 patients - 14.2%), laparotomy and biopsy (1 patient - 4.7%), and laparotomy and reduction of intussusception (1 patient - 4.7%).
Figure 4: Resected small bowel mass lymphoma

Click here to view


Histopathology [Figure 5] revealed 15 (71.4%) BL and 6 (28.6%) diffuse large B-cell lymphoma.
Figure 5: H & E, x100 Burkitt's lymphoma with starry sky appearance

Click here to view


Thirteen (61.9%) patients completed chemotherapy and on follow-up ranging from 1 to 6 years with no evidence of recurrence. One patient is currently undergoing chemotherapy. There were 8 mortalities (38.1%) in our study. All succumbed during chemotherapy; 6 patients due to progressive disease, one due to uncontrolled sepsis, and the other due to a complication of central venous access.

Stage of the disease (P - 0.0068) and diffuse disease at presentation (P - 0.0176) were found to be associated significantly with increased mortality whereas age, sex, site of involvement, primary/secondary disease, surgical intervention, and histopathology did not show statistically different outcome [Table 3].
Table 3: Prognostic factors of bowel lymphoma

Click here to view



  Discussion Top


Pediatric gastrointestinal tract lymphoma (PGTL) is rare yet the most common bowel malignancy in childhood.[6] It constituted only 54 (1.2%) of 4547 pediatric malignancy cases registered between 1952 and 1996.[7] The mean age of our study is similar to peak age for NHL of GI tract in children mentioned in the literature, i.e., 5–15 years.[7] The male to female ratio of childhood GI NHL [2] is reported to be from 7:1 to 1.8:1 which is similar to our study.

Small and large intestines are the most commonly involved sites in pediatric age group unlike adult patients in whom stomach is the most common site (50%–60%).[6] Most of the pediatric patients present with lymphoma involving distal small bowel (50%–93%) but can occur anywhere in the GI tract.[8] Our study shows terminal ileum (81%) is the most common site of involvement.

The most common presenting symptom is reported to be abdominal pain, followed by mass per abdomen [2] and our study follows this order. Nearly, half of children with GI NHL have tumor infiltrates confined to GI tract with possible regional lymph node involvement.[2] Our study showed localized disease in 61.8% cases.

The ultimate treatment approach in GI lymphoma remains debatable. Recent studies have proposed the use of chemotherapy alone as an effective treatment option in primary GI lymphoma in all stages.[9] Surgery is reserved for complications such as obstruction, perforation, and bleeding. Despite disagreements regarding treatment, the disease stage at presentation and extent of involvement remain the most important criteria determining survival.[2],[6] Our study showed that advanced Stage (III and IV) at presentation and diffuse disease at presentation carry increased mortality.

The overall 5- and 10-year survival rates of pediatric GI lymphoma cases treated with combined surgery, chemotherapy, and radiation remain 52% and 44%, respectively.[8] Our study showed 61.9% patients are free of disease and on follow-up.

Differential diagnosis includes enteritis, inflammatory bowel disease, leiomyoma, leiomyosarcoma, or gastrointestinal stromal tumor.

Our study has an interesting finding that lymphoma can either mimic or present with intussusception. About 50% of the study group had radiological intussusception.


  Conclusion Top


Bowel lymphoma in children preferentially involves ileum. Chemotherapy is the mainstay of treatment in bowel lymphoma. Diffuse disease and advanced Stage (III and IV) at presentation are poor prognostic factors, associated with high risk of mortality. In children presenting with recurrent intussusception and beyond the typical age group of idiopathic intussusception (3 years), lymphoma is to be ruled out.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Niharika P, Mobarak AK, Epari SR, Rama MR. Paediatric malignancies. J Clin Diagn Res 2012;6:674-7.  Back to cited text no. 1
    
2.
Bandyopadhyay R, Sinha SK, Chatterjee U, Nag D, Mukhopadhyay S, Chowdhury SR, et al. Primary pediatric gastrointestinal lymphoma. Indian J Med Paediatr Oncol 2011;32:92-5.  Back to cited text no. 2
[PUBMED]  [Full text]  
3.
Kassira N, Pedroso FE, Cheung MC, Koniaris LG, Sola JE. Primary gastrointestinal tract lymphoma in the pediatric patient: Review of 265 patients from the SEER registry. J Pediatr Surg 2011;46:1956-64.  Back to cited text no. 3
    
4.
Dawson IM, Cornes JS, Morson BC. Primary malignant lymphoid tumours of the intestinal tract. Report of 37 cases with a study of factors influencing prognosis. Br J Surg 1961;49:80-9.  Back to cited text no. 4
    
5.
Murphy SB. Classification, staging and end results of treatment of childhood non-Hodgkin's lymphomas: Dissimilarities from lymphomas in adults. Semin Oncol 1980;7:332-9.  Back to cited text no. 5
    
6.
Morsi A, Abd El-Ghani Ael-G, El-Shafiey M, Fawzy M, Ismail H, Monir M, et al. Clinico-pathological features and outcome of management of pediatric gastrointestinal lymphoma. J Egypt Natl Canc Inst 2005;17:251-9.  Back to cited text no. 6
    
7.
Bethel CA, Bhattacharyya N, Hutchinson C, Ruymann F, Cooney DR. Alimentary tract malignancies in children. J Pediatr Surg 1997;32:1004-8.  Back to cited text no. 7
    
8.
Skinner MA, Plumley DA, Grosfeld JL, Rescorla FJ, West KW, Scherer LR, et al. Gastrointestinal tumors in children: An analysis of 39 cases. Ann Surg Oncol 1994;1:283-9.  Back to cited text no. 8
    
9.
Raina V, Sharma A, Vora A, Shukla NK, Deo SV, Dawar R, et al. Primary gastrointestinal non Hodgkin's lymphoma chemotherapy alone an effective treatment modality: Experience from a single Centre in India. Indian J Cancer 2006;43:30-5.  Back to cited text no. 9
[PUBMED]  [Full text]  


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
   Abstract
  Introduction
   Materials and Me...
  Results
  Discussion
  Conclusion
   References
   Article Figures
   Article Tables

 Article Access Statistics
    Viewed507    
    Printed9    
    Emailed0    
    PDF Downloaded91    
    Comments [Add]    

Recommend this journal