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Indian Journal of Medical and Paediatric Oncology
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Year : 2018  |  Volume : 39  |  Issue : 4  |  Page : 503-515

Revised myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia


1 Department of Hematology, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India
2 Division of Medical Oncology, RK Birla Cancer Center, SMS Medical College Hospital, Jaipur, Rajasthan, India
3 Department of Hematology, NRS Medical College, Kolkata, West Bengal, India
4 Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
5 Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India
6 Department of Clinical Hematology, Gauhati Medical College and Hospital, Guwahati, Assam, India
7 Department of Hematology, All India Institute of Medical Sciences, New Delhi, India
8 Department of Hematopathology, Lifeline Tapadia Diagnostic Centre, Hyderabad, Telangana, India
9 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
10 Division of Medical Oncology, Apollo Cancer Hospitals, Hyderabad, Telangana, India
11 Department of Hematology, Center for Stem Cell Transplantation and Research, Army Research and Referral Hospital, New Delhi, India
12 Department of Hematology, Institute of Hematology and Transfusion Medicine, Medical College, Kolkata, West Bengal, India
13 Centre of Excellence in Histopathology, SRL Diagnostics, Mumbai, Maharashtra, India
14 Department of Medical Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India
15 East India Hematological Centre, Guwahati, Assam, India
16 Department of Clinical Hematology, Tata Medical Centre, Kolkata, West Bengal, India
17 Ashirwad Hematology Centre, Mumbai, Maharashtra, India
18 Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
19 Division of Laboratory Medicine, Tata Medical Center, Kolkata, West Bengal, India

Correspondence Address:
Prof. Hemant Malhotra
Division of Medical Oncology, RK Birla Cancer Center, SMS Medical College Hospital, Jaipur, Rajasthan
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmpo.ijmpo_88_17

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Myeloproliferative neoplasms (MPNs) are clonal disorders, derived from abnormal hematopoietic stem cells and result in an excessive production of blood cells. This MPN group of conditions encompasses different diseases with overlapping clinical and biologic similarities. The majority of the conventional therapies of MPN are palliative in nature. However, with the discovery of Janus Kinase 2 (JAK2) mutation and development of targeted JAK1/2 inhibition therapy, the therapeutic options in treatment landscape have changed dramatically. This article presents the revised Indian MPNs Working Group consensus recommendations. It highlights and brings into attention about the recent findings that have defined the state of the art of the diagnosis and therapy in the MPN area, including identification of the new driver and prognostic mutations, treatment goals in the management of myelofibrosis and polycythemia vera (PV), role of the recently approved, targeted tyrosine kinase inhibitor ruxolitinib in PV, and special issues such MPN consideration in patients with splenic vein thrombosis and the management of the disease in pregnancy.


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