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Indian Journal of Medical and Paediatric Oncology
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Year : 2018  |  Volume : 39  |  Issue : 4  |  Page : 524-526

Pneumomediastinum and subcutaneous emphysema in the neck, axilla, and chest regions in a patient with olfactory neuroblastoma treated with chemoradiotherapy

Department of Radiotherapy and Radiodiagnosis, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India

Correspondence Address:
Dr. Radha Kesarwani
Apartment Number L-2, Moti Lal Nehru Medical College Campus, Lowther Road, Allahabad - 211 001, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmpo.ijmpo_85_17

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Spontaneous pneumomediastinum and subcutaneous emphysema in the neck, axilla, and chest do not commonly occur after neoadjuvant cisplatin/etoposide chemotherapy, followed by radiotherapy, and adjuvant cisplatin/etoposide chemotherapy in patients with olfactory neuroblastoma. There are few case reports of pneumomediastinum induced by and occurring during bleomycin/etoposide/cisplatin chemotherapy in testicular cancer. The present case differs from the previous cases in that our patient developed spontaneous pneumomediastinum and subcutaneous emphysema in the neck, axilla, and chest approximately 2 months after completion of chemoradiotherapy for olfactory neuroblastoma. These conditions may have been treatment induced or caused by breath-holding after forceful inspiration. The latter would have created a massive pressure gradient between the alveoli and surrounding structures, causing alveolar rupture, and subsequent passage of air into the mediastinum and subcutaneous tissue of the neck, axilla, and chest.

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