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Indian Journal of Medical and Paediatric Oncology
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CASE REPORT
Year : 2018  |  Volume : 39  |  Issue : 4  |  Page : 530-532

Recurrent metastatic high-grade osteosarcoma: Disease stabilization and successful pregnancy outcome following aggressive multimodality treatment


1 Department of Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, California 94609; Department of Hematology/Oncology, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana 46202, USA
2 Department of Pediatric Hematology/Oncology, University of Missouri School of Medicine, Columbia, Missouri 65201, USA
3 Department of Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, California 94609; Department of Pediatric Hematology/Oncology, University of Missouri School of Medicine, Columbia, Missouri 65201, USA

Correspondence Address:
Dr. Bindu Kanathezhath Sathi
Department of Pediatric Hematology/Oncology, University of Missouri School of Medicine, 404 N Keene Street, Columbia, Missouri 65201
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmpo.ijmpo_83_17

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Prognosis for refractory/recurrent metastatic osteosarcoma (OS) remains dismal with 3-year survival rates <20%. Achievement of more than 5 years of stable, refractory/recurrent metastatic OS disease in our patient is itself unique and attributable to multimodality therapy. Her high-dose chemotherapy regimen with alkylating agents did not lead to infertility, making her case even more unique. Successful disease stabilization and pregnancy outcome in our patient with metastatic multiple relapsed OS is one of the first cases published. We need further understanding and exploration of pathogenesis, chemoresistant mechanisms, and multimodality therapies including immunotherapy for OS.


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