|LETTERS TO EDITOR
|Year : 2018 | Volume
| Issue : 4 | Page : 557-558
Concurrent hairy cell leukemia and chronic lymphocytic leukemia: Diagnostic and therapeutic implications
Parameswaran Anoop1, Channappa N Patil1, Venkatachalam Sandhya2, Sonal Dhande1, Kalpana Janardan3, Shivali Ahlawat4
1 Department of Hemato-Oncology, Apollo Hospitals, Bengaluru, Karnataka, India
2 Department of Pathology, Apollo Hospitals, Bengaluru, Karnataka, India
3 Department of Internal Medicine, Apollo Hospitals, Bengaluru, Karnataka, India
4 Department of Hematopathology, Oncquest Laboratories, New Delhi, India
|Date of Web Publication||15-Nov-2018|
Dr. Parameswaran Anoop
Consultant Hematologist, Apollo Hospitals, 154/11, Opposite IIM, Bannerghatta Road, Bangalore - 560 076, Karnataka
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Anoop P, Patil CN, Sandhya V, Dhande S, Janardan K, Ahlawat S. Concurrent hairy cell leukemia and chronic lymphocytic leukemia: Diagnostic and therapeutic implications. Indian J Med Paediatr Oncol 2018;39:557-8
|How to cite this URL:|
Anoop P, Patil CN, Sandhya V, Dhande S, Janardan K, Ahlawat S. Concurrent hairy cell leukemia and chronic lymphocytic leukemia: Diagnostic and therapeutic implications. Indian J Med Paediatr Oncol [serial online] 2018 [cited 2019 Oct 16];39:557-8. Available from: http://www.ijmpo.org/text.asp?2018/39/4/557/245505
Coexistence of two separate monoclonal hematological cancers poses challenges both from the diagnostic as well as therapeutic perspectives. We describe the concurrent hairy cell leukemia (HCL) and chronic lymphocytic leukemia (CLL) in a previously healthy person.
A 68-year-old male presented with bicytopenia and 7 cm splenomegaly. There were no B-symptoms, jaundice, or lymphadenopathy. Complete blood count showed a hemoglobin of 6 g/dl, total WBC count 8100/mm3, neutrophils 9%, lymphocytes 90%, and platelets 28000/mm3. Direct Coombs test was negative. Peripheral smear examination confirmed lymphocytosis with numerous small mature lymphocytes with clumped chromatin, many smudge cells and a few medium-sized lymphocytes with indistinct nucleoli, weakly basophilic cytoplasm, and irregular “hairy” margins [Figure 1]a and [Figure 1]b. Immunophenotyping revealed lymphocytosis with 8% of cells strongly expressing CD25, CD11c, CD103, and CD123, characteristic of HCL. However, 70% of lymphocytes were positive for CD5, CD23, CD79b, SMIg and negative for FMC-7, typical of CLL [Figure 1]c. Trephine biopsy showed hypercellular marrow with lymphoid infiltration comprising of widely spaced mononuclear cells surrounded by clear spaces (“fried egg” appearance) consistent with HCL [Figure 1]d.
|Figure 1: (a) Peripheral smear with 3 chronic lymphocytic leukemia cells (solid arrows), 2 hairy cells (dashed arrows), 2 smudge cells, and severe thrombocytopenia (b) higher magnification of the 2 hairy cells (c) distinct chronic lymphocytic leukemia and hairy cell leukemia clonal population on flow cytometry (d) trephine biopsy demonstrating typical “fried egg” appearance of hairy cell leukemia and diffuse infiltration by chronic lymphocytic leukemia (e) peripheral smear 3 months after cladribine treatment, showing persistence of chronic lymphocytic leukemia cells (solid arrows), disappearance of hairy cells and normal platelet count (f) flow cytometry 3 months after cladribine treatment, showing complete resolution of hairy cell leukemia clone|
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In the absence of leukocytosis and diffuse marrow infiltration, his CLL was considered to be of Binet stage A and hence not warranting treatment. Bicytopenia and splenomegaly were attributed to HCL, which was treated with cladribine 0.14 mg/kg/day infusion over 2 h for 5 consecutive days. Three months later, the patient was asymptomatic with no splenomegaly, hemoglobin 12 g/dl, WBC 6800/mm3, neutrophils 19%, lymphocytes 74%, monocytes 2%, and platelets 202000/mm3. Peripheral smear [Figure 1]e and flow cytometry [Figure 1]f confirmed total disappearance of HCL clone and persistence of CLL. Patient continues to have no indication for treatment of CLL and will be monitored regularly.
CLL is the most common hematological cancer and can be found incidentally in conjunction with other clonal malignancies. Coexistence of CLL with mantle cell lymphoma and melanoma in a lymph node has previously been reported. In a large retrospective review of 270 patients with CLL, Giné et al. had identified 3 cases of concurrent HCL. Optimal evaluation of peripheral smear morphology can help to suspect such a dual diagnosis. The additional investigations such as flow cytometry, bone marrow biopsy, and immunoglobulin chain rearrangement studies should be used appropriately to confirm the same. In most such patients, CLL is not the cause for the clinical features, and hence, priority should be to treat the coexistent HCL.
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Addada J, Anoop P, Swansbury JG, Wotherspoon A, Thomas JM, Matutes E, et al.
Synchronous mantle cell lymphoma, chronic lymphocytic leukaemia and melanoma in a single lymph node. Acta Haematol 2010;123:194-6.
Giné E, Bosch F, Villamor N, Rozman M, Colomer D, López-Guillermo A, et al.
Simultaneous diagnosis of hairy cell leukemia and chronic lymphocytic leukemia/small lymphocytic lymphoma: A frequent association? Leukemia 2002;16:1454-9.