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Indian Journal of Medical and Paediatric Oncology
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CASE REPORT
Year : 2019  |  Volume : 40  |  Issue : 3  |  Page : 435-439

Pediatric primary pleural synovial sarcoma: A unique case report with brief review of literature


1 Department of Pediatric Hematology/Oncology, Bone Marrow Transplantation and Cellular Therapy, Memorial Sloan Kettering Cancer Center, NY, USA
2 Department of Pediatric Hematology/Oncology, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA
3 Department of Pathology, UH Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA

Correspondence Address:
Anant Vatsayan
Department of Pediatric Hematology/Oncology, Bone Marrow Transplantation and Cellular Therapy, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, NY 10065
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmpo.ijmpo_233_17

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Synovial sarcoma (SS) primary to the pleura is an extremely rare tumor. So far, only nine cases have been reported in pediatric patients. However, none of these patients was found to have a conglomeration of tumors. Here, we report a case of 16-year-old female with monophasic SS and synchronous occurrence of left paraspinal ganglioneuroma and a right paraovarian cystadenoma. A next-generation sequencing genetic panel revealed a novel variant of unknown significance in the MET gene. The occurrence of multiple different tumors in a young patient with a novel genetic variant in a known oncogene (MET) may suggest a possibility of a hitherto unknown cancer predisposition syndrome. We also present a brief review of primary pleural SS reported in pediatric patients.


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