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Indian Journal of Medical and Paediatric Oncology
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Year : 2019  |  Volume : 40  |  Issue : 4  |  Page : 594  

Malignancy-associated microangiopathic hemolytic anemia and thrombocytopenia

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Submission11-May-2018
Date of Acceptance21-Jun-2018
Date of Web Publication17-Feb-2020

Correspondence Address:
Prof. Mahmood Dhahir Al-Mendalawi
P. O. Box: 55302, Baghdad Post Office, Baghdad
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmpo.ijmpo_111_18

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How to cite this article:
Al-Mendalawi MD. Malignancy-associated microangiopathic hemolytic anemia and thrombocytopenia. Indian J Med Paediatr Oncol 2019;40:594

How to cite this URL:
Al-Mendalawi MD. Malignancy-associated microangiopathic hemolytic anemia and thrombocytopenia. Indian J Med Paediatr Oncol [serial online] 2019 [cited 2020 Apr 2];40:594. Available from: http://www.ijmpo.org/text.asp?2019/40/4/594/278504


Abdulla et al. nicely described two Indian patients who presented with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia due to disseminated malignancy (DM).[1] I presume that underlying human immunodeficiency virus (HIV) infection might contribute to the revelation of DM in the studied two patients. That contribution could be addressed in dual aspects. On the one hand, it is obvious that patients with HIV infection have increased tendency to have various neoplastic lesions compared to healthy individuals. The increased propensity of neoplasms among HIV-positive patients has been thought to be related to different factors, including coinfection with oncogenic viruses, immunosuppression, and life prolongation secondary to the use of antiretroviral therapy.[2] To the best of my knowledge, HIV infection is a significant health hazard in India. The available data pointed out 0.26% HIV seroprevalence compared with a global average of 0.2%.[3] On the other hand, thrombotic microangiopathy is associated with HIV infection [4] and it could be the first clinical manifestation of HIV infection.[5] I presume that implementing the diagnostic workup of viral overload and CD4 count estimations was solicited in the studied two patients. If that diagnostic workup was accomplished and it revealed underlying HIV infection, the two cases in question could be truly regarded novel case reports. This is because concurrent HIV infection and DM uncovered by MAHA and thrombocytopenia have never been reported in the literature so far.

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There are no conflicts of interest.

  References Top

Abdulla MC, Alungal J, Nair LK, Musambil M. Malignancy associated microangiopathic hemolytic anemia and thrombocytopenia. Indian J Med Paediatr Oncol 2018;39:254-6.  Back to cited text no. 1
  [Full text]  
Valencia Ortega ME. Malignancies and infection due to the human immunodeficiency virus. Are these emerging diseases? Rev Clin Esp 2018;218:149-55.  Back to cited text no. 2
Paranjape RS, Challacombe SJ. HIV/AIDS in India: An overview of the Indian epidemic. Oral Dis 2016;22 Suppl 1:10-4.  Back to cited text no. 3
Gilardin L, Malak S, Schoindre Y, Galicier L, Veyradier A, Coppo P. Human immunodeficiency virus-associated thrombotic microangiopathies. Rev Med Interne 2012;33:259-64.  Back to cited text no. 4
Sarmiento M, Balcells ME, Ramirez P. Thrombotic microangiopathy as first manifestation of acute human immunodeficiency virus infection: A case report and review of the literature. J Med Case Rep 2016;10:152.  Back to cited text no. 5


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