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Indian Journal of Medical and Paediatric Oncology
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Year : 2020  |  Volume : 41  |  Issue : 1  |  Page : 66  

An unusual site and presentation of sarcoma

1 Department of Pathology, Government Medical College, Kota, Rajasthan, India
2 Department of Oncosurgery, Pushpadi Cancer Care Centre, Kota, Rajasthan, India
3 Department of Pathology, Vhistoplus Diagnostic Centre, Ahmedabad, Gujarat, India

Date of Submission10-Feb-2020
Date of Acceptance13-Feb-2020
Date of Web Publication24-Apr-2020

Correspondence Address:
Dr. Lakshmi Agarwal
Government Medical College, Kota, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmpo.ijmpo_52_20

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How to cite this article:
Agarwal L, Agrawal M, Gandhi S. An unusual site and presentation of sarcoma. Indian J Med Paediatr Oncol 2020;41:66

How to cite this URL:
Agarwal L, Agrawal M, Gandhi S. An unusual site and presentation of sarcoma. Indian J Med Paediatr Oncol [serial online] 2020 [cited 2020 May 28];41:66. Available from: http://www.ijmpo.org/text.asp?2020/41/1/66/283113

A 60-year-old woman presented with multiple bilateral cervical lymphadenopathy, unexplained fever, and weight loss. Hemogram revealed normal complete blood count with hemoglobin 12.8 g/dL, leukocytes 7000/mm3, and platelets 2 lakhs/mm3. Lactate dehydrogenase was 1200 IU/L and uric acid was 8 mg/dL. Contrast-enhanced computed tomography of the head and neck and chest showed no significant abnormality. Ultrasonography of the abdomen was normal. Fine-needle aspiration of the node was done, and smear showed singly scattered cells with scant cytoplasm and irregular nuclear contour and conspicuous nucleoli. The diagnosis of lymphoma was rendered. Excision biopsy of the node was done. Microscopically, lymph node architecture was completely replaced by tumor cells. The cells were small with little cytoplasm and arranged in alveolar spaces. The sheets of cells were separated by fibrous septae and cells adhered to the periphery of alveoli. Mitosis was brisk [Figure 1].
Figure 1: (a-d) Neoplastic cells arranged in alveolar spaces separated by fibrous septae. The cells are small with scant cytoplasm and are adhering to the periphery of alveoli. Mitosis is brisk. (a = H and E, ×4; b = H and E, ×10; c = H and E, ×20; d = H and E, ×40)

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On immunohistochemistry (IHC), tumor cell was positive for desmin and myogenin and negative for CD45 and CD20. The final diagnosis of alveolar rhabdomyosarcoma (RMS)-lymphadenopathic form was given. It is the most common malignant soft-tissue tumor of childhood, but rare in adulthood, occurring in fewer than 5%. The lymphadenopathic form of alveolar RMS shows lymph node involvement as the first clinical manifestation in the absence of recognizable primary tumor. Differential diagnosis of small, round blue cell tumor should be considered and excluded by morphology and IHC.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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There are no conflicts of interest.


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