http://www.ijmpo.org/currentissue.asp Table of Contents:Indian J Med Paediatr Oncol 2009 - 30(2) Pathy Sushmita, Chander Subhash Review Article Indian Journal of Medical and Paediatric Oncology 2009 30(2):55-600971-5851 Pathy Sushmita, Chander Subhash

Indian Journal of Medical and Paediatric Oncology 2009 30(2):55-60

Pancreatic cancer patients present late in their course and surgical resection as a modality of treatment is of limited value. Majority develop loco-regional failure and distant metastasis, therefore, adjuvant therapy comprising of radiotherapy and chemotherapy are useful treatment options to achieve higher loco-regional control. Specialized irradiation techniques like intra-operative radiotherapy that help to increase the total tumor dose have been used, however, controvertible survival benefit was observed. Various studies have shown improved median and overall survival with chemoradiotherapy for advanced unresectable pancreatic carcinoma. The role of new agents such as topoisomerase I inhibitors also needs further clinical investigations.]]> http://www.ijmpo.org/article.asp?issn=0971-5851;year=2009;volume=30;issue=2;spage=55;epage=60;aulast=Pathy Rajarajeswaran P, Vishnupriya R Review Article Indian Journal of Medical and Paediatric Oncology 2009 30(2):61-700971-5851 Rajarajeswaran P, Vishnupriya R

Indian Journal of Medical and Paediatric Oncology 2009 30(2):61-70

Physical exercise has attracted increased interest in rehabilitation of oncological patients. The purpose of this paper is to review the literature and summarize the evidence of physical exercise in preventing cancer, its ability in attenuating the effect of cancer and its treatments and to provide guidelines for exercise prescription Review of recent literature by electronic search of MEDline (Pub Med), Cancer lit, Cochrane libraries, CINAHL were done using Keywords and the variables were identified and systematically evaluated. There is strong evidence for reduced risk of colorectal and breast cancer with possible association for prostate, endometrial and lung cancer with increasing physical activity. Exercise helps cancer survivors cope with and recover from treatment; exercise may improve the health of long term cancer survivors and extend survival. Physical exercise will benefit throughout the spectrum of cancer. However, an understanding of the amount, type and intensity of exercise needed has not been fully elucidated. There is sufficient evidence to promote exercise in cancer survivors following careful assessment and tailoring on exercise prescription. ]]> http://www.ijmpo.org/article.asp?issn=0971-5851;year=2009;volume=30;issue=2;spage=61;epage=70;aulast=Rajarajeswaran Labani Lakshmi, Andallu B, Meera M, Asthana S, Satyanarayana L Original Article Indian Journal of Medical and Paediatric Oncology 2009 30(2):71-750971-5851 Labani Lakshmi, Andallu B, Meera M, Asthana S, Satyanarayana L

Indian Journal of Medical and Paediatric Oncology 2009 30(2):71-75

Background: The uterine cervix is the second most common site of cancer among Indian women.Though the human papillomavirus has been demonstrated to be a causative agent for this cancer, a variety of other risk factors are in play, such as sexual and reproductive patterns, socioeconomic, hygienic practices, and diet. The accumulated evidence suggests that cervical cancer is preventable and is highly suitable for primary prevention. The dietary intake of antioxidants and vitamins like vitamin A, carotenoids, vitamin C, folacin and tocopherol is found to have protective effects against cancer of the cervix. Dietary data regarding cervical cancer are still scanty. Objective: The present study was therefore undertaken to study the dietary pattern among uterine cervical cancer patients and normal controls. Materials and Methods: A total of 60 consecutive patients and 60 controls were enrolled from a referral hospital during the year 2004. A schedule inclusive of the food frequency pattern and 24-h dietary recall along with the general information was administered to all the enrolled subjects to describe findings on the food consumption pattern along with other important factors. Results: The mean intake of energy, protein, vitamins, etc., between the cases and controls was not significantly different except for the vitamin C level. Serum vitamin E was found to have lower average in patients as compared to controls. The nutrient intake of cervical cancer patients and controls was grossly deficient in the socioeconomic group studied. With regard to the macronutrient intake, calorie and protein intakes showed a deficit of around 50% when compared to RDA. Conclusion: The food consumption profile was not significantly different between cervical cancer patients and normal controls.]]> http://www.ijmpo.org/article.asp?issn=0971-5851;year=2009;volume=30;issue=2;spage=71;epage=75;aulast=Labani Haque Saadiya, Kirk Robert van Original Article Indian Journal of Medical and Paediatric Oncology 2009 30(2):76-790971-5851 Haque Saadiya, Kirk Robert van

Indian Journal of Medical and Paediatric Oncology 2009 30(2):76-79

Background : The relationship between Hodgkin's lymphoma (HL) and plasma cell-type Castleman's disease (PCD) has been well documented. There have been over 20 cases reported in the literature and nearly all of them were either diagnosed concurrently, or were initially diagnosed as PCD and upon review were found to have interfollicular HL. Human herpes virus type 8 (HHV-8) is present in about 40% of cases with PCD. It predisposes patients to a much higher risk of other malignancies, including Kaposi's sarcoma and non-Hodgkin's lymphoma. Cases linked to HHV-8 are associated with a different morphology than cases that are not linked to HHV-8. It has been proposed that patients with both HL and CD will have lymph nodes with HHV-8-negative morphology. Materials and Methods : We present a series of three cases in a retrospective study where patients had both HL and PCD. Surgical pathology reports, clinical histories, and H and E and various immunohistochemical stains on initial work-up were examined and subsequent immunohistochemical stains for HHV-8 were obtained from the Methodist Hospital. Results: Patient 1 was diagnosed with PCD and interfollicular HL in the same lymph node. Patient 2 was first diagnosed with classic HL and 2 years later returned with enlarged lymph nodes clinically suspected to be recurrent HL. Histology showed angiofollicular hyperplasia and interfollicular plasmacytosis without Reed-Sternberg cells and a diagnosis of PCD was rendered. Patient 3, a male in his third decade, was diagnosed with nodular sclerosing HL in the thymus, and concurrently PCD in the mediastinal lymph nodes. All three cases had architectural features consistent with an HHV-8-negative morphology. Immunohistochemical stains for HHV-8 were done retrospectively and were negative. Conclusion: All three of our patients with both HL and CD had HHV-8-negative lymph node morphology and absence of HHV-8 by immunohistochemistry. These patients, therefore, are not at an increased risk for the development of subsequent malignancies, when compared to HHV-8-positive patients. Included in our series is one unique case where the diagnosis of HL preceded CD by 2 years.]]> http://www.ijmpo.org/article.asp?issn=0971-5851;year=2009;volume=30;issue=2;spage=76;epage=79;aulast=Haque Srikantia Nirmala, Rekha B, Rajeev A G, Kalyan Suman N Case Report Indian Journal of Medical and Paediatric Oncology 2009 30(2):80-830971-5851 Srikantia Nirmala, Rekha B, Rajeev A G, Kalyan Suman N

Indian Journal of Medical and Paediatric Oncology 2009 30(2):80-83

Endometrial adenocarcinoma is the third common malignancy of the female genital tract occurring most often in the postmenopausal age group. High tumor grade, advanced surgical stage, and lymphovascular space invasion are implicated as poor prognostic factors for dissemination of disease. We present an unusual case of endometrial adenocarcinoma in a premenopausal woman with simultaneous metastases in brain, liver, skin and skeletal system, within one month of completion of treatment. The role of adjuvant/concurrent chemotherapy in addition to radiotherapy in high risk cases is discussed along with the review of literature.]]> http://www.ijmpo.org/article.asp?issn=0971-5851;year=2009;volume=30;issue=2;spage=80;epage=83;aulast=Srikantia Parelkar Sandesh, Joshi Milind Case Report Indian Journal of Medical and Paediatric Oncology 2009 30(2):84-860971-5851 Parelkar Sandesh, Joshi Milind

Indian Journal of Medical and Paediatric Oncology 2009 30(2):84-86

Thyroid malignancy is an uncommon tumor of the pediatric population. Patients can present with asymptomatic thyroid nodule and it requires thorough work up to rule out the malignancy. Radiological and pathological procedures are a standard part of the management. A 10-year-old girl had asymptomatic thyroid nodule; the cytological examination and the frozen section and final histology of the nodule was different each time. The girl had to undergo total thyroidectomy on the basis of histology of the nodule which was well differentiated papillary carcinoma of thyroid and is under regular follow-up for last two years on thyroid supplementation.]]> http://www.ijmpo.org/article.asp?issn=0971-5851;year=2009;volume=30;issue=2;spage=84;epage=86;aulast=Parelkar Krishna Mohan M.V.T, Rajappa Senthil J, Reddy T Vamshidhar, Paul T Roshni Case Report Indian Journal of Medical and Paediatric Oncology 2009 30(2):87-890971-5851 Krishna Mohan M.V.T, Rajappa Senthil J, Reddy T Vamshidhar, Paul T Roshni

Indian Journal of Medical and Paediatric Oncology 2009 30(2):87-89

Malignant melanoma is rare in India; melanoma presenting as a metastatic disease with an unknown primary, involving the gastrointestinal tract without involving lymph nodes is extremely uncommon. We report a case of a 28-year-old male with a malignant melanoma metastasizing to stomach and liver with an unknown primary. Relevant literature is being reviewed. ]]> http://www.ijmpo.org/article.asp?issn=0971-5851;year=2009;volume=30;issue=2;spage=87;epage=89;aulast=Krishna