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Indian Journal of Medical and Paediatric Oncology
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   1996| September  | Volume 17 | Issue 3  
    Online since May 30, 2009

 
 
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Ultrastructural peroxidase reaction in acute unclassifiable leukemias.
S Bajpai, SC Shinde, CN Nair, Y Badrinath, SR Dhond, Kumar MS Ashok, RS Sapre, AB Chogule, SH Advani
September 1996, 17(3):147-151
Ultrastructural myeloperoxidase was evaluated in 41 cases of acute leukemias of indeterminate lineage. The morphology, cytochemistry and surface marker studies were inconclusive for any specific lineage and therefore these could not be classified according to the F.A.B criteria. Based on cytochemical and immunophenotyping results we could identify 37 patients with myeloperroxidase(MPO)Negativity along with absent lymphoid and myeloid surface markers(Group A)and 4 patients with low MPO(1-2 )positivity(Group B).Further studies for MPO and platelet peroxidase(PPO)at ultrastructural level were helpful to identify the lineage in 17 of the 41(42.8)of our patients. The need of ultrastructural peroxidase demonstration to identify the nature of morphologically and cytochemically undifferentiated blasts is highlighted.
[ABSTRACT]   Full text not available   
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Gestational trophoblastic diseases.
PM Fisher, Barry W Hancock
September 1996, 17(3):126-133
The gestational trophoblastic diseases, including complete and partial hydatidiform mole, choriocarcinoma and placental site tumour, are uncommon complications of pregnancy. Increasing maternal age and a previous molar pregnancy are the two main risk factors for development of these rare conditions. Abnormal vaginal bleeding is the usual means of presentation but upto a third of patients with choriocarcinoma first present with widely disseminated disease. Human chorionic gonadotrophin plays an important role as a tumour maker, with elevated levels confirming the diagnosis and also providing a valuable method of monitoring response to treatment. The majority of patients require no further treatment following termination of pregnancy, with less than 10 patients registered in the United Kingdom proceeding to chemotherapy. The most appropriate chemotherapeutic regimen is chosen by assessing the patients. It is essential that a specialist team is involved from the outset in order to prevent unnecessary complications and to identifiy those patients that require a change in treatment strategy at an early stage.
[ABSTRACT]   Full text not available   
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Malignant melanoma as an unknown primary with CNS metastasis.
R Goyal, BS Parikh, BJ Saikia, PM Parikh, CS Soman, SH Advani
September 1996, 17(3):152-154
Malignant melanoma presents rarely as metastasis from an unknown primary. We report one such case which presented as metastasis to the Central Nervous System with an unknown primary.
[ABSTRACT]   Full text not available   
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The role of TDF and ERD concepts in concurrent radiotherapy-5 FU chemotherapy treatment for carcinoma of base of tongue.
H Vaithianathan, SS Supe, V Kannan, DC Doval, N Anantha, Vaithianathan Hema
September 1996, 17(3):141-146
Fourty four patients with histopathologically proven squamous cell carcinoma of base tongue were treated with concurrent Radiotherapy and Chemotherapy(RT+CT)during 1987-1989. All patients were treated with a combination of Cobalt-60 teletherapy and Chemotherapy with 5-Flurouracil. External radiotherapy(EXRT)dose varied from 40 Gy to 71Gy in 20 to 37 fractions over 28 to 70 days. Treatment results in terms of response rate, status and complication rate were correlated with Dose. Time dose Fractionation factor(TDF)and Extrapolated Response Dose(ERD). There was a sharp increase in mucositis and overall complication rates with increasing dose. The complication rate increased beyond a dose of 50 Gy(p=NS). There was a sharp increase in response rate beyond a dose of 50 Gy(p,0.005). Mucositis and overall complication rates did not correlate with TDF(p=NS). A sharp increase in nodal and overall response rate beyond a TDF of 80(p0.005)was noted. Mucosistis and overall complication rates indicated lack of correlation with ERD(
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Gonadal function in survivors of acute lymphoblastic leukemia after treatment with aggressive chemotherapy.
G Kapoor, SJ Vaidya, SK Pai, R Joseph, A Seth, SB Moodbidri, CS Soman, SH Advani
September 1996, 17(3):135-140
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Dexarazoxane.
KP Sajnani, P Sajnani Kamalesh
September 1996, 17(3):157-159
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