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Indian Journal of Medical and Paediatric Oncology
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Year : 1995  |  Volume : 16  |  Issue : 1  |  Page : 15-20

Neo-adjuvant/adjuvant chemotherapy in non-metastatic extremity osteosarcoma.


Cancer Institute(WIA) Adyar, Madras, India

Correspondence Address:
PVSS Sripada
Cancer Institute(WIA) Adyar, Madras, India

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Source of Support: None, Conflict of Interest: None


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The aim of this study is to see the impact of neoadjuvant and adjuvant chemotherapy in non-metastatic classic osteosarcoma of the extremity, over a 5year period in our Institute. Fourty three Patients between May 1989 and May 1994 were studied. Group A numbering 15 patients received neoadjuvant chemotherapy.3 cycles preoperatively and 3 cycles of adjuvant chemotherapy after ablative surgery. The chemotherapy consisted of Ifosfamide, Adriamycin and Cisplatin in bot groups. Ther results were analysed applying Kaplan-Meier product limit method for survival and logrank test for predicting statistical significance. In Group AII(73.3 percent) patients are metastasis free with post chemotherapy grade III and IV necrosis being seen in only 4 patients(26.7 percent). In Group B 20(71.4 percent) patients are metastasis free. The 5 year survival is 76.2 percent in Group A and 60.2 percent in Group B. Neoadjuvant/adjuvant chemotherapy with Adriamycin, Cisplatin and Ifosfamide combination significantly improves the outcome in patients of non-metastatic extremity osteosarcoma and it is important to diagnose the disease early for planning preoperative chemotherapy and limb sparing surgery.\


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