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Indian Journal of Medical and Paediatric Oncology
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Year : 1995  |  Volume : 16  |  Issue : 2  |  Page : 108-114

A twelve year study of multiple myeloma at the all india institute of medical sciences, new delhi, india.

Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
P Gupta
Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

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Source of Support: None, Conflict of Interest: None

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A review of 146 cases records of multiple myeloma at the All India Institute of Medical Sciences, New Delhi, in India, from a period of 12 years revealed a predominance of this disease in younger individuals(mean age 52 years) of male gender(Male:Female ration 2.24:1). Significant anemia(Hb8.5g/dl) at presentation was seen in 40 percent and renal impairment in 37 percent patients. The response rate to a 4 drug combination (Vincristine, melphalan,cyclophosphamide and prenisolone:Group II) was better(73 percent) compared to a 2 drug combination including either cyclophosphamide or melphalann alon with prednisolone:Group I(43 percent:p less than 0.05). The median duration of response and median survival in Group II(12.5 and60 months respectively) however, were not significantly different from those in Group I(17 and 42.7 months respectively). These results support the presence of geographical variations in the clinical characteristics of multiple myeloma; treatment response and survival, however, are not different from those observed elsewhere.

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