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| Year : 1995 | Volume
: 16
| Issue : 3 | Page : 177-182 |
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Central nervous system toxicity of high dose cytosar(hdac) : report of 2 cases and review of literature.
R Kamble, B Kslam, L Kumar, V Kochupillai
Institute Rotary Cancer Hospital, New Delhi, India
Correspondence Address:
R Kamble
Institute Rotary Cancer Hospital, New Delhi, India
 Source of Support: None, Conflict of Interest: None  | Check |
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High dose cytosine arabinoside(2-3 gm/m2 12 hourly for 8-10 doses) is often used as consolidation therapy for the management of acute myeloid leukemia(AML). Cytosine arabinoside(Ara-C) in this dose, produces significant neurotoxocity and life threatening myelotoxicity. Over the last two years, 15 patients were administered Ara-C in the dose of 1.5-2 gms/m2 12 hrly x 10 doses as post remission consolidation therapy, three(20 percent) died due to septicemia, secondary to myelotoxicity; 2(including one who died: 13 percent) developed grade II to III neurotoxicity. Neurotoxic complications of high dose Ara-C are discussed in detail. Since intermediate dose Ara-C (0.5-1.0 gms/m2 12 hrly x 8-10 doses) is found to be as effective as high dose Ara-C, such dose is recommended to avoid high morbidity and mortality related to high dose Ara-C. |
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