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Indian Journal of Medical and Paediatric Oncology
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Year : 1995  |  Volume : 16  |  Issue : 4  |  Page : 213-218

Intraperitoneal cisplatin in the management of malignant ascites.

P. Medical College, Bikaner, Rajasthan, India

Correspondence Address:
A Sharma
P. Medical College, Bikaner, Rajasthan, India

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Source of Support: None, Conflict of Interest: None

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20 patients with malignant ascites were treated with intraperitoneal(IP) cisplatin which included 16 cases of carcinoma ovary and one case each of cancer breast, colon, stomach and mesothelioma of peritoneum. Out of 20 patients, 16 patients had excellent local control of disease with absence of effusion and improving Karnofsky's scale upto 90 to 100 percent(14 cases of cancer ovary and one case each of carcinoma breast and mesothelioma of peritoneum). Two cases , one ach of carcinoma colon and stomach, and two cases of carcinoma ovary with advanced disease did not respond to intraperitoneal cisplatin. Infusions of cisplatin were generally well tolerated by the patients. No sign of myelosuppression, nephrotoxicity, neuropathy or ototoxicity was observed in the present study. Acute toxicity consisting of mild nausea, vomiting(Grade 1-2 according to WHO scale)and anorexia was observed in most of patients. The results obtained in the current study suggest that intraperitoneal cisplatin is an effective therapy for immediate control of malignant ascites with minimal side effects.

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