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Indian Journal of Medical and Paediatric Oncology
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Year : 1996  |  Volume : 17  |  Issue : 1  |  Page : 23-31

Chromosome sensitivity studies in patients with down syndrome.


Dept of Cancer Biology, The Gujarat Cancer & Research Institute, Ahmedabad, India

Correspondence Address:
RK Patel
Dept of Cancer Biology, The Gujarat Cancer & Research Institute, Ahmedabad, India

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Source of Support: None, Conflict of Interest: None


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Spontaneous and Bleomycin(BLM) induced chromosome aberration frequencies were assessed in 20 Down syndrome patients and 20 normal controls. Peripheral blood lymphocyte cultures were exposed to BLM during the last 5 hrs (late S-G2phase) of incubation. The findings showed significantly higher rates of chromatid-type aberrations(CA/cell)as well as chromatid-type + chromosome-type aberrations(TA/cell) in untreated cells as well as BLM-treated cells of the Down syndrome patients compared to normal individuals. After excluding gaps from CA/cell and TA/cell, only spontaneous rates were higher among DS patients. Whereas BLM induced aberrations without gap were comparable among both the groups of individual. Results of the present study support the hypothesis that individuals with Down syndrome have a high rate of spontaneous chromosomal aberrations which may contributing to their higher risk of developing cancer.


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