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Indian Journal of Medical and Paediatric Oncology
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Year : 1996  |  Volume : 17  |  Issue : 1  |  Page : 32-39

Rhabdomyosarcoma in children :clinical features and results of an aggressive chemotherapy regimen.


Tata Memorial Hospital, Bombay, India

Correspondence Address:
G Kapoor
Tata Memorial Hospital, Bombay, India

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Source of Support: None, Conflict of Interest: None


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The aim of the present article was to study the pattern of pediatric rhabdomyosarcoma and the results of an aggressive chemotherapy regimen, in a setting where radical surgery may not always be feasible. Twenty seven consecutive patients. 0-20 years of age, registered at the Tata Memorial Hospital between March 1989 and march 1993 were evaluated. All patients were treated with multi-modality approach. A significantly large number of patients presented with parameningeal head and neck disease(30)and extremity lesions(22). In addition most patients had advanced disease(96 had IRS clinical group III or IV disease)at presentation. Complete response rate was 67 and overall and disease free survival at the end of 2 years was 42.5 and 29. Loco-regional relapse or disease progression was the main cause of mortality. Myelosuppression was the major toxicity observed with this chemotherapy schedule.


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