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Indian Journal of Medical and Paediatric Oncology
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Year : 1996  |  Volume : 17  |  Issue : 1  |  Page : 40-44

Unusual second malignancies in childhood retinoblastoma.


Medical Oncology Dept, Tata Memorial Hospital, Bombay, India

Correspondence Address:
M Gera
Medical Oncology Dept, Tata Memorial Hospital, Bombay, India

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Source of Support: None, Conflict of Interest: None


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Patients with heritable retinoblastoma have a substantial risk of developing second malignant tumor. The incidence of second malignant tumors increases with time. The commonest second malignancy is usually osteosarcoma. The Rb gene provides a genetic basis for this observation, as there is a risk of developing a second malignancy among children with germline Rb mutations irrespective of treatment. Here we report two unusual second malignancies-a pleomophic spindle cell squamous carcinoma and a peripheral nerve sheath sarcoma arising in treated patients of bilateral and unilateral retinoblastoma respectively.


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