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Indian Journal of Medical and Paediatric Oncology
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Year : 1996  |  Volume : 17  |  Issue : 2  |  Page : 102-106

Leukoencephalopathy following single dose of intrathecal methotrexate in a child with acute lymphoblastic leukemia.


Dept of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India

Correspondence Address:
SJ Vaidya
Dept of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India

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Source of Support: None, Conflict of Interest: None


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Intrathecal Methotrexate forms an integral part of presymptomatic therapy for central nervous system leukemia in acute lymphoblastic leukemia. Here we report a case of ALL with an unusual complication in the form of leukoencephalopathy after a single dose of intrathecal methotrexarte in the absence of CNS leukemia. The patient had a complete neurological recovery and his further antileukemic therapy was given without cranial radiotherapy and intrthecal methotrexate. The patient has been in complete remission for the past 30 months and neurologically normal.


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