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Indian Journal of Medical and Paediatric Oncology
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Year : 1996  |  Volume : 17  |  Issue : 2  |  Page : 90-98

Mine therapy for patients with resistant or relapsed or relapsed non hodgkins lymphoma.


Dept of Medical Oncology, Pathology & Computing, Tata Memorial Hospital, Bombay, India

Correspondence Address:
R Nair
Dept of Medical Oncology, Pathology & Computing, Tata Memorial Hospital, Bombay, India

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Source of Support: None, Conflict of Interest: None


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Twenty five patients with resistant or relapsed Non Hodgkins lymphoma were treated with a combination of mesna with iphosphamide,nonvantrone(mitozantrone),and etoposide(MINE). All patients had previously been treated with a combination of methotrexate, doxorubicin,cyclophosphamide.oncovin, prednisolone, and bleomycin(MACOP-B). Complete remission was obtained in 9(36)and the overall response was 72. The median survival for patients achieving a complete remission was 21 months and for patients with a partial response was 7.5 months(p=0.003). The regimen was well tolerated and myelosuppression was the commonest toxicity. There were no treatment related deaths. The stage of disease, presence of symptoms,bulk of the tumor and histology at initial presentation had no impact on survival. The response to intial therapy and disease free interval after the first line chemotherapy were significantly associated with response to MINE and survival.


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