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Indian Journal of Medical and Paediatric Oncology
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Year : 1996  |  Volume : 17  |  Issue : 3  |  Page : 141-146

The role of TDF and ERD concepts in concurrent radiotherapy-5 FU chemotherapy treatment for carcinoma of base of tongue.

Dept of Radiation Physics, Kidwai Memorial Institute of Oncology, Bangalore, India

Correspondence Address:
H Vaithianathan
Dept of Radiation Physics, Kidwai Memorial Institute of Oncology, Bangalore, India

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Source of Support: None, Conflict of Interest: None

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Fourty four patients with histopathologically proven squamous cell carcinoma of base tongue were treated with concurrent Radiotherapy and Chemotherapy(RT+CT)during 1987-1989. All patients were treated with a combination of Cobalt-60 teletherapy and Chemotherapy with 5-Flurouracil. External radiotherapy(EXRT)dose varied from 40 Gy to 71Gy in 20 to 37 fractions over 28 to 70 days. Treatment results in terms of response rate, status and complication rate were correlated with Dose. Time dose Fractionation factor(TDF)and Extrapolated Response Dose(ERD). There was a sharp increase in mucositis and overall complication rates with increasing dose. The complication rate increased beyond a dose of 50 Gy(p=NS). There was a sharp increase in response rate beyond a dose of 50 Gy(p,0.005). Mucositis and overall complication rates did not correlate with TDF(p=NS). A sharp increase in nodal and overall response rate beyond a TDF of 80(p0.005)was noted. Mucosistis and overall complication rates indicated lack of correlation with ERD(

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