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Indian Journal of Medical and Paediatric Oncology
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Year : 1996  |  Volume : 17  |  Issue : 4  |  Page : 178-184

Lactate dehydrogenase and its isoenzymes in serum from patients with neoplastic disorders.


Choithram Hospital and Research Centre, Indore, India

Correspondence Address:
B Nigam
Choithram Hospital and Research Centre, Indore, India

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Source of Support: None, Conflict of Interest: None


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A study of lactate dehydrogenase (LD)and its isoenzymes was undertaken in the sera of patients with neoplastic disorders. In recent years, the relationship between neoplasia and LD has been studied with increasing intensity. The present study included 161 patients with neoplastic disorders, classified as Multiple myeloma (42),Gastro intestinal malignancies(27), Urogenital malignancies(22),Leukemia(16), Carcinoma Lung(14),Lymphoma(11),Head and neck cancers(8),Bone tumours(4), Carcinoma breast(12)Neurological malignancies(2), malignant melanoma(1),Choriocarcinoma(1),and Carcinoid(1). The other group of 21 patients with othermonocloanl gammopathies were also studied which included patients with infection(7)and patients with immunological disease(14). The study revealed an increase in the total serum LD activity with an increase in LD, fraction and decrease in LD2 fraction. The study indicates that serum total LD and isoenzymes pattern may be of diagnostic importance in neoplastic disorders encountered in clinical practice.


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