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Indian Journal of Medical and Paediatric Oncology
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Year : 1997  |  Volume : 18  |  Issue : 4  |  Page : 121-126

Sister chromatid exchange frequencies in patients with down syndrome


The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India

Correspondence Address:
AH Trivedi
The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India

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Source of Support: None, Conflict of Interest: None


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Spontaneous and mutagen induced Sister Chromatid Exchange (SCE) frequencies were assessed among 16 Down syndrome (DS) patients and 15 healthy controls. The spontaneous SCE rates were comparable in both the groups. MMC-induced SCE frequencies were significantly lower in DS patients as compared to the controls. However, the number of cells with high frequency of spontaneous SCEs was three times higher in DS patients as compared to controls. Thus, the present study on MMC-induced SCE frequencies is not sufficient to evaluate the risk of neoplasia in DS patients. Further study with different mutagen as well as cytogenetic end point e.g. chromosome aberration frequency will be helpful in understanding the risk of malignancy among DS patients.


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