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Indian Journal of Medical and Paediatric Oncology
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Year : 1998  |  Volume : 19  |  Issue : 1  |  Page : 9-12

Acute promyelocytic leukaemia : the era of ATRA.


Department of Medical Oncology Regional Cancer Centre, Thiruvananthapuram

Correspondence Address:
VP Gangadharan
Department of Medical Oncology Regional Cancer Centre, Thiruvananthapuram

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Source of Support: None, Conflict of Interest: None


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Acute Promyelocytic leukaemia (APL) is a rare type of leukaemia representing 5-15 per cent cases of ANLL1. The characteristic chromosomal translocation involving chromosomes 15 and 172, increased propensity for DIC3,4 and the dramatic response to All Trans Retinoic Acid (ATRA), make APL unique among acute leukemias. Remission induced by ATRA has to be consolidated 5,6. Therapeutic options in treating DIC is controversial. We analysed 6 cases of APL treated with ATRA; 40 percent achieved a complete remission (CR)


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