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Indian Journal of Medical and Paediatric Oncology
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Year : 1998  |  Volume : 19  |  Issue : 2  |  Page : 62-67

Autologus bone marrow transplantation and hepatic venocculsive disease



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PM Parikh


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Hepatic venocclusive disease(VOD) is a major cause of morbidity and mortality in patients undergoing autologous bone marrow transplantation (ABMT). We therefore analysed 180 patients with AML (33) or lymphoma (HD 100, NHL 47) undergoing ABMT over 6.5 years for VOD using McDonald's criteria. Twenty two of them developed VOD. Incidence was higher with regimen containing irradiation (16 percent versus 4 percent, P=0.05) for females(20 percent versus 7 percent, p=0.02) and patients autografted for NHL (17 percent versus 11 percent, p=0.04). Preexisting hepatic dysfunction (n=6) did not seem to increase the chance of VOD.


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