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Indian Journal of Medical and Paediatric Oncology
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Year : 1998  |  Volume : 19  |  Issue : 2  |  Page : 68-72

Malignant cell susceptibility to preservation : possible purging effect in transplantation


AIIMS, New Delhi, India

Correspondence Address:
GMK Raju
AIIMS, New Delhi, India

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Source of Support: None, Conflict of Interest: None


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Cell viability and progenitor cell recoveries of hemopoietic cells have been measured following storage at 4C in a refrigerator. The mean end viability of normal bone marrow cells was 69.7 percent with a progenitor cell recovery of 61.0 percent on the 14th day of storage. Whereas marrow cells of multiple myeloma patients (who underwent autologous BMT) had a viability of 67.4 percent with a stem cell recovery of 60.2 percent on day 9 and for many leukemic state bone marrow samples the end viability was 60.5 percent on day 5 with a progenitor cell recovery of 59.5 percent Preferential cytolysis of the contaminating malignant cells in both multiple myeloma and leukemic state bone marrows could be the possible explanation for these differences.


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