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Indian Journal of Medical and Paediatric Oncology
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Year : 1998  |  Volume : 19  |  Issue : 3  |  Page : 83-89

Combination of netilmicine (once daily or thrice daily) with either ceftriaxone ar ampicillin cloxacilin as emperical therapy for febrile neutropenic patients


Gujarat Cancer & Research Institute, Ahmedabad

Correspondence Address:
SV Nath
Gujarat Cancer & Research Institute, Ahmedabad

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Source of Support: None, Conflict of Interest: None


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Febrile neutropenia is a frequent complication in patients undergoing treatment for neoplastic disease. The optimum emperic antibiotic regimen consists of an aminoglycoside and B-lactum antibiotic. The safety and efficacy of once a day dose of netilmicin has been investigated in febrile neutropenic patients in this study. Thirty six patients were randomised into three groups. Group I consisted of Netilmycin and Ceftriaxone administration in single daily dose. In group II, Netilmycin was administered three times a day with single dosing of Ceftriaxone while in Group III single dosing of Netilmycin was combined with Ampicillin and Cloxacillin. The mean duration of neutropenia was similar in the three groups. The commonest site of infection was the respiratory tract. Once a day administration of antibiotics was more convenient as in group I and two patients could take treatment on an outpatient basis. Once a day administration of Ceftriaxone and Netilmycin is as effective as three times daily dosing of netilmicin with once daily ceftriaxone and can be considered as an emperical line of treatment for patients with febrile neutropenia.


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