Home | About IJMPO | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Indian Journal of Medical and Paediatric Oncology
Search Article 
  
Advanced search 
 
Year : 1999  |  Volume : 20  |  Issue : 1  |  Page : 10-15

Interferon alpha-2B in patients of acute lymphoblastic leukemia afflicted with chronic hepatitis B : early observations.


1 Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Amadawad 380 016, India

Correspondence Address:
KP Sajnani
Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Amadawad 380 016, India

Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

AIM: To investigate the efficacy and safely of interferon (IFN) therapy in patients with acute lymphatic leukaemia (ALL) with chronic hepatitis B (CHB). PATIENTS & METHODS: 22 patients of ALL, who were in complete remission after completion of the planned treatment and with HBsAG and HBeAg positive reports for more than 6 months, received IFN in 2 dose schedules (1) 3 miu subcutaneously (SC) daily for 4 weeks and 3 miu subcutaneously twice in a week for 12 weeks (2) 3 miu SC twice in a week for 16 weeks. Eighteen were males and 4 were females, aged from 7 years to 19 years (Median 13 years). Pretreatment serum alamine aminotransferase (ALT) was normal in 9 and elevated in 13. HBV DNA was positive in all patients. Median follow up was 13.6 months (range : 8 months to 36 months). RESULTS: Normalisation of ALT occured in 8 of 13 (61.5 percent) patients with elevated values before the administration of interferon. Mean time to achieve normalisation of ALT was 6.2 months after start of IFN. Eight of 22 patients (36 percent) became HBeAg negative and 2 of 6 patients, who were tested by HBV-DNA, became HBV-DNA negative after treatment. The only side effect observed was fever in 4 patients and it was managed with paracetamol. This study showed : (1) a good rate of biochemical and virologic response to IFN in patients of ALL with CHB. (2) Response to IFN was dependent on pretreatment ALT values. CONCLUSIONS: IFN is safe and effective in patients of ALL afflicted with CHB.


[PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed620    
    Printed39    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal