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Indian Journal of Medical and Paediatric Oncology
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Year : 2005  |  Volume : 26  |  Issue : 1  |  Page : 12-19

Granulosa cell tumours of ovary : variables affecting prognosis


Dept. of Medical Oncology, AIIMS; New Delhi, India

Correspondence Address:
N Vimla
Dept. of Medical Oncology, AIIMS; New Delhi, India

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Source of Support: None, Conflict of Interest: None


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Background: Granulosa cell tumours account for less than 5 percent of all ovarian malignancies. Limited data is available from India. Methods: 27 patients with diagnosis of granulosa cell tumour of the ovary were treated between 1991 and 2003 at our Institute. The surgical records were reviewed and the patients were staged according to the FI6O system. The clinical and histological findings are correlated with prognosis and survival. Results: Mean age at diagnosis was 46.2 (2-64) years. The numberof patients in various stages was 1-19; II-l; III-5 and IV-2. Menstrual irregularity was diagnosed in 22 percent, and postmenopausal bleeding in 7.4 percent of women. Twenty-five patients were treated with primary surgery, 9 patients received adjuvant chemotherapy (CT) and only one patient received chemotherapy as primary treatment. Overall survival was 82 percent at 5 years. Overall survival for stage I was 100 percent after 5 and 10 years and in stage II-IV, was 56.4 percent after 5 and 10 years. Meantumour size was 18cm (range 3-30 cm). Women with larger tumour diameter (greater than 15cm) had significantly worse outcome than those with tumours of smaller diameter (P less than 0.05). The frequency of observed mitosis influenced the survival rate; with 0-3/10, HPF the survival was 100 percent in 5 years and with 4/10, HPF the survival was 2.6 years. Conclusion: The tumour size, mitotic rate and stage of disease are well-defined variables and influence the survival significantly and should be considered as important prognostic factors for treatment planning.


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