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Indian Journal of Medical and Paediatric Oncology
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Year : 2005  |  Volume : 26  |  Issue : 4  |  Page : 16-24

Pathology of Gall bladder carcinoma in India : An overview


Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar New Delhi-110029

Correspondence Address:
CS Kiran
Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar New Delhi-110029

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Source of Support: None, Conflict of Interest: None


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In comparison to the western world gallbladder carcinoma (GB) is common in India. Etiology of Gallbladder cancer is of multifactorial in origin. Long history of gall stone diseases ( greater than 20 years), size of stone, high parity, advanced age, ethnicity, chemical carcinogens, specially tobacco and coffee intake, have been attributed. Early point mutation of codon 12 of the K-ras oncogene in gallbladder carcinoma has been identified. Pathology of gallbladder shows wide spectrum of changes starting from inflammatory, metaplastic, dysplastic changes of malignancy. Adenocarcinoma is the most common type of invasive GB carcinoma and shows many variations. Size of GB carcinoma can be tiny to large mass infiltrating the liver. Sometimes thickening of wall is the only evidence. It is required to know the correct technique of processing and sectioning of GB specimens to correctly diagnose the disease, as it has a very high mortality rate.


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