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Indian Journal of Medical and Paediatric Oncology
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Year : 2005  |  Volume : 26  |  Issue : 4  |  Page : 61-66

Chemotherapy in gallbladder cancer : A clinical Review


Rajiv Gandhi Cancer Institute and Research Centre, New Delhi

Correspondence Address:
DC Doval
Rajiv Gandhi Cancer Institute and Research Centre, New Delhi

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Source of Support: None, Conflict of Interest: None


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The role of palliative chemotherapy in Gallbladder Cancer (GBC) has been studied in multiple phase II trials utilizing various drugs like 5 Flourouracil, Cisplatin, Gemcitabine, etc. as single agents and in combinations. Most trials have combined biliary tract cholangiocarcinomas along with gallbladder adenocarcinomas. The prognosis and response among these two groups varies enough to warrant focused research on GBC. The available data points towards a role of chemotherapy in GBC. Further research is needed to study the impact of chemotherapy in overall survival, and quality of life in inoperable disease; and to define the role of adjuvant chemotherapy in a subset of patients with operable disease. The optimal choice of chemotherapeutic agents, also needs to be defined.


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