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Indian Journal of Medical and Paediatric Oncology
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Year : 2008  |  Volume : 29  |  Issue : 3  |  Page : 1 Table of Contents     

Gastric lymphoma and epstein-barr virus

Pediatric Haematology Oncology,Centre for Child Health, Sir Ganga Ram Hospital, New Delhi 110 060, India

Date of Web Publication30-May-2009

Correspondence Address:
Veronique Dinand
Pediatric Haematology Oncology,Centre for Child Health, Sir Ganga Ram Hospital, New Delhi 110 060
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-5851.51412

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How to cite this article:
Dinand V. Gastric lymphoma and epstein-barr virus. Indian J Med Paediatr Oncol 2008;29:1

How to cite this URL:
Dinand V. Gastric lymphoma and epstein-barr virus. Indian J Med Paediatr Oncol [serial online] 2008 [cited 2020 Oct 22];29:1. Available from: https://www.ijmpo.org/text.asp?2008/29/3/1/51412

Epstein-Barr virus (EBV) is the major biological cofactor contributing to a number of human cancers including B-cell neoplasms (Burkitt's lymphoma, Hodgkin's lymphoma (HL and immunoblastic lymphomas, certain forms of Tcell lymphoma, and some epithelial tumours (nasopharyngeal carcinomas and gastric carcinomas). Recent studies have revealed the association of EBV with about 10% of gastric carcinoma cases worldwide. EBV DNA in cancer biopsies shows monoclonality, indicating that carcinoma arises from a single EBV-infected cell. [1]

Primary malignant gastric lymphomas account for less than 15% of gastric malignancies. Most gastric lymphomas are B-cell lineage NHL. They usually arise from mucosal associated lymphoid tissue (MALT). Other types of gastric lymphomas include diffuse large B-cell lymphomas, mantle cell lymphomas and T cell lymphomas. [2]

Seventy to 100% of MALT lymphoma cases are associated with Helicobacter pylori, a bacterium proven to be the cause of gastritis and peptic ulcer and the progression to gastric carcinoma. Lower H. pylori infection rates have been reported in gastric lymphoma in Asian populations (50%-60%). [3]

Gastric lymphoma association with EBV has not been extensively studied. The pilot study by Sood et al published in this issue of Journal reports EBV detection in neoplastic cells in 36% of 11 cases, [4] higher than reports from Hong Kong, Korea and China (2% to 8% in series of 53, 33 and 49 cases respectively). [3],[5] However, the small sample size does not allow any meaningful conclusion.

Detection of EBV in tumour cells by immunohistochemistry or in situ hybridization is no proof of its implication in the pathogenesis. EBV might either play a role in the development of gastric lymphoma, particularly in H. pylori negative cases, or be present in neoplastic cells as a secondary phenomenon. Demonstration of EBV clonality in EBV-associated gastric lymphomas would be able to give a definitive answer.[6]

  References Top

1.Imai S, Koizumi S, Sugiura M, et al. Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc Natl Acad Sci U S A 1994;91(19):9131-9135.  Back to cited text no. 1      
2.WHO classification of tumours of the digestive system: Hamilton SR, Aaltonen LA, eds. Tumours of the digestive system. World Health Organization classification of tumours. Lyon: ARC Press, 2000.   Back to cited text no. 2      
3.Xu WS, Ho FC, Ho J, et al. Pathogenesis of gastric lymphoma: the enigma in Hong Kong. Ann Oncol. 1997;8 Suppl 2:41-44.   Back to cited text no. 3      
4.Sood A, Braganza A& T Rajalakshmi, Epstein-Barr Virus in gastric lymphoma-An Indian Perspective Ind. J Med& Paed Oncol 2008;29(3):5-9.   Back to cited text no. 4      
5.Liu Q, Ohshima K, Masuda Y, Kikuchi M. Detection of the Epstein-Barr virus in primary gastric lymphoma by in situ hybridization. Pathol Int 1995;45(2):131-136.   Back to cited text no. 5      
6.Yang WI, Cho MS, Tomita Y, et al. Epstein-Barr virus and gastrointestinal lymphomas in Korea. Yonsei Med J 1998;39(3):268-276.  Back to cited text no. 6      


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