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Indian Journal of Medical and Paediatric Oncology
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Year : 2008  |  Volume : 29  |  Issue : 3  |  Page : 2-6

Epstein-barr virus in gastric lymphoma- An Indian perspective

Department of Pathology, St. John's Medical College, Bangalore - 560034, India

Correspondence Address:
T Rajalakshmi
Department of Pathology, St. John's Medical College, Bangalore - 560034
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-5851.51413

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Background : Primary Gastric Non- Hodgkin's Lymphomas (NHL) are being increasingly encountered in the recent years. While the role of Helicobacter pylori (H. pylori) has been explored in its causation, some studies have suggested the role of the Epstein - Barr virus (EBV). However data from India is not readily available and this prompted us to study the morphology of primary gastric NHL, the prevalence of EBV infection in primary Gastric NHL and study its association with H. pylori infection. Materials & Methods : A retrospective study. Sixteen biopsy proven cases of primary gastric NHL were studied. Histologic features were reviewed. Immunohistochemistry for EBV LMP-1 and Modified Giemsa stain to identify Helicobacter pylori were done. Results : There were 10 low-grade and 6 highgrade lymphomas, 15 of them classifiable as Mucosa-associated lymphoid tissue (MALT) type, owing to the presence of lymphoepithelial lesions. 36% of the cases were EBV positive. Only one case showed H. pylori. 4 patients succumbed to the disease, of which 3 were seropositive for HIV. Conclusion : Our pilot study suggests that EBV may have an important role in the pathogenesis of gastric MALT lymphomas. The significance of this association and its prognostic value need to be explored in larger number of patients.

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