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Indian Journal of Medical and Paediatric Oncology
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Year : 2020  |  Volume : 41  |  Issue : 4  |  Page : 608-611

Takatsuki syndrome – Not really a polyneuropathy, organomegaly, endocrinopathy, M-spike, and skin change!!!

1 Department of General Medicine, Unit 1V, Christian Medical College, Vellore, Tamil Nadu, India
2 Department of Medical Oncology, K. S. Hegde Medical Academy, NITTE Deemed to be University, Deralakatte, Karnataka, India

Correspondence Address:
Dr. Vijith Shetty
Department of Oncology, OPD No 50, K. S. Hegde Hospital, Deralakatte - 575 018, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijmpo.ijmpo_137_19

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Polyneuropathy, organomegaly, endocrinopathy, M-spike, and skin changes (POEMS) is a rare multisystem disorder, with its prevalence in India being 1 in 330,000. It is a demyelinating neuropathy accompanied by dermatoendocrine syndrome. The cause of POEMS is unknown. The diagnosis of POEMS syndrome requires two mandatory criteria plus more than one major and more than one minor criterion. A middle-aged male with no known comorbidities from South India presented with complaints of burning micturition, increased frequency of micturition, and pain in the abdomen for 3 weeks. The patient was evaluated earlier at another center with a rise in serum creatinine from 1.9 to 2.9 mg/dl within a span of 3 days. The patient had pleural effusion, hypercalcemia, renal failure, and splenomegaly with lytic lesions. Due to the presence of typical skin lesions with polyneuropathy, workup for POEMS was carried out. Positron-emission tomography scan and vascular endothelial growth factor levels were checked and fulfilled the criteria. Early treatment was initiated, and POEMS has a good prognosis. As POEMS is very rare, early diagnosis improves the outcome.

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