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Indian Journal of Medical and Paediatric Oncology
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PRACTITIONER SECTION
Year : 2020  |  Volume : 41  |  Issue : 5  |  Page : 770-772

A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management


1 Department of Medical Oncology, Artemis Hospital, Gurugram, Haryana, India
2 Department of Blood Bank and Transfusion Medicine, Artemis Hospital, Gurugram, Haryana, India

Correspondence Address:
Dr. Amit Kumar Jain
Department of Medical Oncology, Artemis Hospital, Sector-51, Gurugram - 122 001, Haryana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmpo.ijmpo_116_20

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Vincristine is a common drug used in hematological malignancy with a maximum per dose limited to 2 mg mainly to limit neurotoxicity. Vincristine overdose and wrong route of administration, though has been reported in world literature, but its appropriate management is still undefined. We report a case of Hodgkin lymphoma being treated with adriamycin, bleomycin, vinblastine and dacarbazine protocol, where vincristine was accidently administrated instead of vinblastine due to its “look-alike, sound-alike” nature. The patient developed severe toxicity due to the same, which was effectively managed by therapeutic plasma exchange.


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