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A rare case of carcinoma of unknown primary in an elderly female: Parotid metastases from gastrointestinal primary
Venkata Pradeep Babu Koyyala1, Sumit Goyal2, Ankush Jajodia3, Manish Sharma1, Manoj Gupta4, BP Amrith1, Jahangir Alam1, Rakshya Shrestha1
1 Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Center, Delhi, India
2 Department of Medical Oncology, Rajiv Gandhi cancer Institute and research center, New Delhi, India
3 Department of Radiology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India
4 Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India
|Date of Submission||26-Feb-2020|
|Date of Decision||15-Mar-2020|
|Date of Acceptance||10-Apr-2020|
|Date of Web Publication||18-Nov-2020|
Venkata Pradeep Babu Koyyala,
Room: 3162, 1st Floor D Block, Rajiv Gandhi Cancer Institute and Research Centre, Sector - 5, Rohini, New Delhi - 110 085
Source of Support: None, Conflict of Interest: None
Parotid gland is a rare site of metastasis from GI tract primary cancer. Here we present an interesting case report of Parotid metastasis from unknown primary with probable Lower gastrointestinal tract as a primary site of cancer, with a normal colonoscopy and upper GI endoscopy. This case report highlights the importance of immunohistochemistry in taking treatement decisons during dillematic situations.
Keywords: Gastrointestinal tract cancer, parotid metastases, unknown primary
|How to cite this URL:|
Koyyala VP, Goyal S, Jajodia A, Sharma M, Gupta M, Amrith B P, Alam J, Shrestha R. A rare case of carcinoma of unknown primary in an elderly female: Parotid metastases from gastrointestinal primary. Indian J Med Paediatr Oncol [Epub ahead of print] [cited 2020 Nov 25]. Available from: https://www.ijmpo.org/preprintarticle.asp?id=300672
| Introduction|| |
The most common sites of metastases from colon cancer are liver, lung, and peritoneum. Metastases to other organs are relatively rare., Metastases to the parotid gland are very is a rare event. The primary sites that can involve parotid gland as a site of metastases are cutaneous melanoma and squamous cell carcinoma of head and neck cancers. Parotid metastasis from colon cancer is extremely rare. We report an interesting case who presented with symptoms related to parotid gland enlargement and finally diagnosed as metastases from lower gastrointestinal tract (GIT), with a possible regressed primary. The primary site is confirmed after an extensive immunohistochemical evaluation.
| Case Report|| |
A 72-year-old female presented to our hospital with the complaints of swelling in the left parotid region for the last 1 month. Examination revealed enlarged parotid gland and enlarged bilateral left cervical and supraclavicular nodes. Skin and breast examination was normal. Magnetic resonance imaging of the face and neck revealed a heterogeneously enhancing mass in the deep lobe of the parotid extending to the superficial lobe measuring 2.4 cm × 2.6 cm × 3 cm with central necrosis. Nodal masses are seen in the bilateral lower, posterior cervical, left infraclavicular areas. Ultrasound-guided biopsy was done from cervical lymph node. Histology was suggestive of high-grade adenocarcinoma. Immunohistochemistry was done, which was positive for CK20, CDX2, and MUC2 and diffusely positive for SATB2 marker and negative for CK7 marker suggestive of primary from the lower gastrointestinal (GI) (colorectal) origin. Positron emission tomography–computed tomography was done [Figure 1], which was suggestive of metabolically active soft tissue lesion involving the deep lobe of the parotid gland and metabolically active enlarged cervical, bilateral supraclavicular, left internal mammary, periportal, pericaval, and paraaortic lymph nodes. There was no other metabolically active disease in the body and GIT. Colonoscopy was done, which revealed no abnormality. Upper GI endoscopy was normal and tumor markers such as CEA, CA19-9, and CA-125 were within normal limits.
She was started on FOLFOX-based palliative chemotherapy. Post 6 cycles, reevaluation was suggestive of good response with decreased swelling in the parotid region with partial response radiologically according to the RECIST criteria. This case highlights the importance of immunohistochemistry in all doubtful cases and those presenting with atypical clinical signs. To our knowledge, this is only the sixth case of parotid metastases from colon cancer, but the first case to present with symptoms of parotid metastases with undetectable colonic primary. Furthermore, metastases to the parotid gland is considered as either a late or terminal event and often considered that treatment is unnecessary in the earlier literature. Palliative chemotherapy was offered to this patient and the patient responded to chemotherapy with symptomatic improvement.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
This study was supported by Rajiv Gandhi Cancer Institute and Research Centre, New Delhi.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
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