Indian Journal of Medical and Paediatric Oncology

: 2020  |  Volume : 41  |  Issue : 5  |  Page : 640--651

COVID-19: A review of the pandemic with emphasis on the role of imaging

Mohnish Bothra1, Tahleel Altaf Shera2, Jyoti Bajpai3, Abhishek Mahajan1,  
1 Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai, Maharashtra, India
2 Department of Radiodiagnosis, Sher I Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
3 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Prof. Abhishek Mahajan
Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai - 400 012, Maharashtra


Heretofore, the COVID-19 pandemic continues to expand costing not just lives but also significant impact on the global economy. More than 212 countries and territories across the globe have been affected till now, causing approximately 4,043,068 confirmed cases and 277,016 deaths, and the numbers are rising expeditiously. The common symptoms are fever, dry cough, fatigue, sputum production, shortness of breath, sore throat, and headache, but atypical symptoms affecting cardiovascular system, gastrointestinal system, and neurological manifestations are not so uncommon and have been reported. Various governing bodies such as the World Health Organization, the National Institute for Health and Care Excellence, and the Centers for Disease Control and Prevention have laid down guidelines and recommendations for the same. In this review article, we have propounded the established knowledge about the causative agent in terms of epidemiological features, the etiopathogenesis, signs and symptoms, methods used for diagnosis, and the latest insight into the treatment and prevention according to the recent published recommendations. The current guidelines and the state-of-the-art updates for various active health-care personnel; allied departments such as radiology and microbiology, and those for the community have also been discussed.

How to cite this article:
Bothra M, Shera TA, Bajpai J, Mahajan A. COVID-19: A review of the pandemic with emphasis on the role of imaging.Indian J Med Paediatr Oncol 2020;41:640-651

How to cite this URL:
Bothra M, Shera TA, Bajpai J, Mahajan A. COVID-19: A review of the pandemic with emphasis on the role of imaging. Indian J Med Paediatr Oncol [serial online] 2020 [cited 2020 Dec 2 ];41:640-651
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Full Text


Patients with COVID-19 may have normal imagingCT thorax may be indicated in patients with negative RT-PCR and having clinical symptoms that are in favor of COVID-19There is no role of chest imaging in mild disease regardless of risk factors and positive test result for COVID-19 but indicated in those showing worsening of dyspnea or hypoxemiaCT may be reserved for patients who have had sudden clinical deteriorationWhen faced with community spread, CT might serve as a tool to diagnose patients with high index of suspicion, however it may still be challenging to differentiate COVID-19 from other atypical pneumoniasIn ICU, patient's point-of-care ultrasound (POCUS) is a viable and logistically practical imaging tool.


The epicenter of the outbreak of new novel coronavirus, now renamed as COVID-19, happened in Wuhan city, Hubei province, China, in December 2019. This highly contagious virus has spread rapidly across the globe with approximately 4,043,068 confirmed cases as of date May 09, 2020[1] [Figure 1]. Coronaviruses (CoV) belong to a large family of viruses; the novel coronavirus (2019-nCoV) being a new strain which has not been previously identified in humans causes illness ranging from the common cold as a minor symptom to more severe respiratory diseases. Hitherto, the high disease burden has led to nearly 277,016 deaths worldwide, with the USA and Spain as the worst-hit countries as of May 9, 2020 [Figure 1]. Amidst the crisis, the health-care establishments and the governments are trying to cope up with the current scenario with day-to-day decisions and coming up with the new guidelines to contain the spread. We present a review article with the emphasis on the virion epidemiology, etiopathogenesis, disease spectrum, role of imaging, and also the treatment and preventive strategies according to the latest available guidelines.{Figure 1}


CoVs belong to the family of Coronaviridae and fall under the Coronaviridae subfamily which is a single-stranded (positive sense) RNA associated with a nucleoprotein within a capsid composed of matrix protein.[2] The envelope bears club or crown-shaped glycoprotein projections. According to Lauer SA et al. the median incubation period was estimated to be in the range of 5.1-15.6 days with an assumption that the 99th percentile of the cases will develop symptoms within 14 days of acquiring the infection.[3] There is an association of age and immunity status of the patient as evident by shorter incubation period seen in patients <70 years of age than in those >70 years.[4] The positive cases (55.1%) in the age range of 15–49 years clearly outnumbered the other groups, which were seen as 28.9% in 50–64 years while 15.1% in age 65 years and above.[5] The World Health Organization (WHO) declared COVID-19 as a public health emergency of international concern.[6]

 Mode of Spread

The predominant mode of spread is via airborne route with human-to-human infection between close contacts (<6 feet) and as a droplet infection when an infected person coughs or sneezes; the infected droplets are either inhaled by the healthy individuals in the vicinity and or land up in the mouth or nose [Figure 2]. The other mode of spread to a healthy individual is via fomites which are infected or contaminated objects having viable virus on their surface.[7] The intermediate source of origin and transfer to humans is unknown; however, the possibility of it being a zoonotic disease (via infected bats) is likely.[8]{Figure 2}


The primary target of the virion is the epithelial cells of the lung with affinity of the receptor-binding domain spike on the envelope of the virus particle to the angiotensin-converting enzyme 2 receptor in the host.[9],[10] After its entry into the host cell, the genome is uncoated and is followed by transcription and translation; the virus replicates in the cells of ciliated epithelium, causing damage to the host cell, and incites inflammation.[11]

 High-Risk Population

This includes the elderly typically 65 years and older; those living in long-term facility and nursing home; people with underlying medical conditions, for example, chronic lung disease, cardiac disease, liver disease, chronic kidney disease, diabetes, and immunosuppression secondary to HIV/AIDS, long-term steroid use, bone marrow and organ transplantation, and cancer patients.[12] Cancer patients undergoing treatment with chemotherapy and radiotherapy, those suffering from hematological neoplasm, or those who have received bone marrow transplant or stem cell transplant as a part of the treatment <6 months' duration or are put on drugs altering the immune systems such as PARP inhibitors or protein kinase inhibitors are the most susceptible among the lot.[13]

 Signs and Symptoms

The signs and symptoms of COVID-19 infection are highly variable and are nonspecific ranging from asymptomatic carrier to typical respiratory symptoms and/or rarely systemic manifestations pertaining to gastrointestinal and cardiovascular systems.[5],[14],[15],[16],[17] In the given current scenario, the symptoms in the pediatric population are milder as compared to the adults.[18],[19] The most common symptoms are fever (87.9%), followed by dry cough (67.7%), fatigue (38.1%), sputum production (33.4%), shortness of breath (18.6%), sore throat (13.9%), headache (13.6%), myalgia/arthralgia (14.8%), chills (11.4%), nausea and vomiting (5.0%), nasal congestion (4.8%), diarrhea (3.7%), hemoptysis (0.9%), conjunctival congestion (0.8%), and acute respiratory distress syndrome (ARDS) (3%).[5] Various societies across the globe are coming up with guidelines and recommendations in various subspecialties; one such example is British Thoracic Society which has published the guidelines for the respiratory community – The clinical classification of cases given by the Chinese clinical guidance for COVID-19 pneumonia diagnosis and treatment (7th ed.ition) is summarized in [Table 1].{Table 1}


The state-of-the-art test for COVID-19 is real-time reverse transcriptase-polymerase chain reaction (RT-PCR). The specimen for endemic forms of human CoV infections has been isolated from various areas, namely, nasal swab or nasopharyngeal (NP), throat, sputum, and bronchoalveolar lavage (BAL). The current Centers for Disease Control and Prevention (CDC) recommend collection of specimens from upper respiratory tract, preferably NP swab.[20] Laboratories are required to maintain the adequate temperature chain to store the specimen, i.e., maintaining refrigerated temperature for up to 72 h or frozen at −70° or even below it.[18] Regarding the biosafety guidelines, the CDC has recommended the BSL 2 laboratories to deal with regulation of the specimen.[21] Early infections may be missed and repeat swabs may be taken for highly suspicious cases later in the course of illness. Serum and rectal specimens alternatively can be used.[22]

Laboratory diagnosis

It mainly consists of a battery of routine blood investigations with few generalized observations such as lymphopenia, which tends to be a poor prognostic indicator.[23] There is a rise in the acute-phase reactants such as C-reactive protein (CRP), lactate dehydrogenase (LDH), prothrombin time (PT), D-Dimer, and liver enzymes. Later, in the disease, there may be rise in the organ-specific proteins and markers, which heralds the poor prognosis of the individual.[23]

 Role of Radiology and Imaging

The role of diagnostic radiology as a tool in the current scenario is being constantly updated with various publications, review articles, and their immediate incorporation into various guidelines given by international and national health governing bodies. The role of screening computed tomography (CT) for COVID-19 has been called off by many radiological societies.[24] Lately, plain radiography and CTs are used as a part of diagnostic armamentarium with acceptable levels of detection and follow-up of cases under specific regulations and indications. Chest radiography despite being less sensitive than CT continues to be used the first radiological investigation across the globe.[25] In conjunction to it, the Indian chest societies such as IRIA ICRI chest subspecialty group have also come up with the same. To minimize the risk of contamination of the radiology department and the radiology personnel, special emphasis is laid on the use of portable radiography using dedicated machinery with defined protocols as directed by various health-care providers across nations and the world.[26]

The radiographic evidence of abnormality is most obvious at 10–12 days after development of symptoms, whereas in the early or mild course of the disease, no abnormality is detected.[25] The sensitivity and specificity of chest radiography is low as compared to that of the CT. The predominant abnormality on radiographs is patchy areas of consolidation (28.1%) followed by ground-glass opacities (GGOs) (20.1%) and rarely interstitial abnormalities (4.4%). These changes were more frequently present in bilateral distribution as seen in a study conducted by Guan et al.[5] Lately, many publications have come up describing the imaging in COVID-19, emphasizing on CT features.[27],[28],[29],[30],[31] These studies were able to decipher the common patterns of lung affection on CT such as GGOs, frequently bilateral and multilobar and infrequently as mass like or nodular pattern of opacities.[31] The classic CT depicter for COVID-19 is diffuse involvement of lungs bilaterally with GGOs rendering crazy paving appearance with or without consolidation predominantly in peripheral and posterior aspect.[27],[28],[29],[30],[31],[32] Lymphadenopathy, pleural effusions, multiple tiny pulmonary nodules, tree in bud pattern, and cavitation have been rarely described in the spectrum as atypical findings and may represent superadded infections.[33] A normal CT chest may be expected early in the course of disease.[34],[35],[36] The sensitivity and specificity of CT varies in the range of 60%–98% and 25%–53%, respectively.[37],[38],[39],[40] [Table 2] - summarises the COVID-19 pneumonia imaging classification.{Table 2}

Recently, there have been recommendations regarding the reporting language for COVID-19 to even out the discrepancy of findings on imaging and maintain homogeneity among the fraternity. The proposed reporting language with the CT findings are adapted from the Society of Thoracic Radiology, the American College of Radiology, and RSNA.[24] [Figure 3]a and [Figure 3]b shows the CT image of a confirmed case of COVID-19. COVID mimics – few examples of mimics of the disease owing to the varied patterns on CT imaging are shown in [Figure 4] and [Figure 5]a,[Figure 5]b,[Figure 5]c,[Figure 5]d.{Figure 3}{Figure 4}{Figure 5}

 Indications of Imaging

The Fleischner society has described the role of imaging and its use in the given setting of the pandemic on the basis of various clinical criteria and their features, as given in [Table 3].[41]{Table 3}


Mild disease: No role of chest imaging in mild disease regardless of risk factors and positive test result for COVID-19 but indicated in those showing worsening of dyspnea or hypoxemiaModerate-to-severe disease: Imaging in patients with positive COVID-19 status is recommended serving as a baseline study, to identify those with underlying cardiovascular disease for risk assessment and assess disease progression and superadded abnormalities and infections.

Other subsets of patients who are either not tested or have a negative test should undergo imaging as a part of routine care and for evaluation of the underlying pathology. If imaging features are suspicious of COVID-19 infection, these cases should be dealt further according to risk factors and lab test availability including repeat tests for COVID-19.

COVID-RADS is another such example and can be used for the structured reporting of the cases in clinical trials and can be accessed at

The lack of dedicated CT units for the suspected patients or cases in a hospital setting and effortful sterilization and low specificity has led to the lack of endorsement in developing countries such as India.[42] The role of ultrasonography (USG) as point of care ultrasound (POCUS) is surging as a tool because of ease of portability and sterilisation techniques, and also, it can be used as dedicated unit in isolation and critical care wards.[43],[44],[45] It has been reinforced by recent studies in China in critical care settings.[46] Its role is being assessed in triage and risk stratification and detection of complications such as pleural effusions. The imaging findings comprise multiple B lines and waterfall sign secondary to thickening of the interlobular septa in subpleural location, areas of focal or diffuse consolidation with air sonograms, and irregular pleural thickening with or without pleural effusion with reduced blood supply on Doppler.[47] The preparation of ultrasound transducer consists of cleaning and disinfection as recommended by the International Society of Ultrasound in Obstetrics and Gynecology with the use of low- or high-level disinfectants compiled and available on 22027, and also the methods and compatibility with the equipment have been already provided by various vendors. The technique of performing ultrasound of chest for the patients has been stipulated by Soldati, et al.,[48] which recommends the use of convex or linear transducers according to the individual patients with low mechanical index <0.7 and suggests to avoid the usage of tissue harmonic imaging, Doppler imaging, compound, and contrast enhancing methods. For those who are not able to maintain a sitting position or are on invasive method of ventilation, the checklist consists of a minimum of eight areas which would amount to the total scan duration of approximately 2–3 min. The region of interest is anteriorly in the mid clavicular line above and below the internipple line, laterally midaxillary line both above and below the internipple line, and posteriorly the base of the lung on both sides.[49] Similarly, for stable patients, they have proposed 14 sites to be examined along the anterior, laterals and posterior aspects of the chest wall.[48]


Treatment and prevention

To this date, no specific antiviral therapy or vaccine is approved by the CDC, the WHO, and the U.S. Food and Drug Administration for the treatment of COVID-19 infection, thus the management of cases is primarily symptomatic and with use of empirical drugs to combat life-threatening conditions secondary to disease progression and superadded infections.[49],[50],[51] The treatment strategy emphasizes on the administration of oxygen and respiratory support through various available methods. What is expected out of the entire remainder of healthy individuals in these trying times is to pay stern attention to meticulous hand hygiene, donning face mask, cough etiquettes, avoid gathering and crowded environments, and self-isolation.[2] All the patients should be screened for symptoms at the entry point of the health care facility as a part of infection prevention and control.[52] The health-care facilities shall follow all the standard precautions, for example, hand hygiene, personal protective equipment (PPE), safe waste management, and cleaning the equipment and environment. The standard operating procedure to be followed in the radiology department by staff and technologists and sanitisation of the CT facility is given in [Table 4]. Milder form of disease does not require any intervention at the health-care facility, but the strict need of isolation and standard precautions to contain the spread are taken care of. Severe respiratory failure should be identified and addressed with supplemental oxygenation with intubation and mechanical ventilation as required to maintain the blood oxygen saturation level. The intricate details of the management pertaining to the drug dosage and ventilator support settings and critical care, etc., are beyond the scope of this review article.{Table 4}

Drug trials

The use of hydroxychloroquine for the high-risk population has been recommended by the National task force for COVID-19 constituted by the Indian Council of Medical Research. The high-risk population includes those health-care workers engaged in the treatment of suspected or confirmed cases of the disease and the household contacts of the laboratory-confirmed cases.[53] However, both chloroquine and hydroxychloroquine have shown activity against SARS-CoV-2in vitro models and have immunomodulating properties, but there is limited data to suggest the potential benefit.[54],[55],[56],[57],[58],[59] Protease inhibitors such as lopinavir and ritonavir have recently failed to confirm the potential benefits in a study.[60]

Remdesivir, a nucleotide analog, is being tested under several large clinical trials and has limited availability, however in the ongoing trials, it has proven to reduce the time to recovery against the placebo group.[61] Tocilizumab as an immunomodulating agent is being used in some acceptable protocols, but the data fall short of proving it as an adjunct therapy.[62] COVID-19 convalescent plasma is also being explored as a potential treatment.[63] Except for refractory shock and severe respiratory distress syndrome, the use of corticosteroids is not recommended.[60],[64],[65] The use of nonsteroidal anti-inflammatory drugs has been doubted to cause clinical worsening; there is lack of clinical data to support or refute, but antipyretics, for example, acetaminophen, are recommended for fever.[60],[66] Azithromycin has been used in conjunction with hydroxychloroquine and benefit has been suggested in preclinical studies.[67]

Cancer and COVID

The morbidity and mortality from COVID is higher in cancer patients (6%–20%) than in the general population (2%–3%).[68] There is possible delay in the treatment of such cancer patients in this crisis owing to the restricted movement due to risk of acquiring infection and also modification in the treatment protocols as per the availability and feasibility which is a cause of major cancer and fear amongst these subset of patients.[69],[70] The treating oncologists are also concerned as they are working in potentially infectious surroundings with suboptimal PPE, which may lead to life-threatening situations.[71] Triaging of patients should be done in a multidisciplinary team with appropriate documentation to avoid or handle any future medicolegal dispute.[72]

Certain principles should be followed to minimize the risk to patients and caregivers

Conscious de-intensification of therapies should be practiced including minimization of intensive systemic therapy protocols with higher risk of complications; prolongation of therapy intervals; avoidance of intravenous route; and preference for oral or subcutaneous route for all the therapies including for ancillary care. Similarly, triaging for surgery considering the risk–benefit ratio stringently needs to be followed. For example, simple surface surgeries such as the breast and the thyroid may be considered with relatively low risk, however, elective aerosol-generating procedures wherein high contamination risk exists should be minimized. For radiation, use of altered fractionation schedules such as hypofractionated UK-FAST and FAST FORWARD regimen of 5 weekly and daily fractions used for cancer such as breast can save machine time and should be considered. Similarly, one may consider using altered fractionation instead of using radiosensitizing concurrent chemotherapy depending on the scenario.

Preventive measures

Simple measures including regular washing of hands with soap and water; usage of alcohol-based sanitizers; avoiding touching eyes, nose, and mouth; maintaining social distancing; following self-isolation; and maintaining at least 1-m distance have been recommended by the CDC [Figure 6] and use of proper fitting N95 face mask. The method of donning and doffing of the face mask and personnel protective equipment has been recommended by the CDC.[73] NIOSH-approved N95 respirators filter out at least 95% of tiny (0.3-μ size) particles that are capable of filtering out all types of particles, including bacteria and viruses. The Government of India ordered lockdown for a period of 21 days on March 24, 2020, as a preventive measure to control the pandemic.[74] The splendid efforts by the Government of India and many other countries, international bodies of concern, and health-care delivery system of the country together with befitting and awake positive acceptance by the individuals of the community in these trying times is the doorway to control the spread of COVID-19 infection and save lives.{Figure 6}


The rapidly spreading COVID-19 pandemic has emerged as a critical challenge to the community and the health-care individuals, placing their lives in jeopardy. The infection continues to spread and various measures are being taken for its containment including rigorous government decisions and emphasis of social distancing, hand sanitization, cough etiquettes, and use of masks to bring down its impact in terms of lives lost and rate of spread of infection. The only available laboratory test is RT-PCR which is variable through the course of illness; other supportive laboratory parameters are lymphopenia, raised erythrocyte sedimentation rate, CRP, LDH, etc., The crucial yet elusive role of imaging has been evolving in parallel with the knowledge of the disease. A summary of the review of the pandemic is given in [Table 5].{Table 5}

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.


The authors would like to thank Dr. Rajat Agrawal, Junior Resident, Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


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