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Indian Journal of Medical and Paediatric Oncology
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   1997| March  | Volume 18 | Issue 1  
    Online since May 30, 2009

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Cll : post radiotherapy for carcinoma palate
R Goyal, BS Parikh, PM Parikh, JS Nadkarni, SH Advani
March 1997, 18(1):17-18
A patient with CLL (Chronic Lymphocytic Leukemia) can present with secondary neoplasms involving skin, lung, prostate, kidney, cutaneous melanoma and haematological malignancies. However CLL as a second neoplasm is rare. A 75 year old male presented to us with squamous cell carcinoma of palate and was treated with neoadjuvant chemotherapy and radiotherapy. Three years later he presented to us with B-phenotypic CLL. The interval to development of radiation induced leukemia is usually 7 years. Our patient either had undiagnosed CLL at presentation of developed early post radiotherapy CLL.
[ABSTRACT]   Full text not available   
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Treatment of post mastectomy lymphoedema of arm with 5,6-benzo-alpha pyrone : a pilot study
TG Sagar, PR Mohan
March 1997, 18(1):9-13
5,6-Benzo-Alpha Pyrone (Coumarin) can reduce the high protein oedema fluid by stimulating proteolysis there by reducing the lymphoedema in postmastectomy arm swelling. We have conducted a pilot study with Coumarin in Twenty cases of postmastectomy lymphoedema of arm. Patients received 400 mg, of the drug daily for six months. During the study the measurement of the arm was taken at fixed points and the volume of the limb measured. After six months of therapy the excess oedema has reduced by more than 50 percent in 21 percent of cases. A minimal reduction of less than 30 percent of excess oedema was observed in 15 percent of cases. Further the symptoms like stiffness, hardness, heaviness of the limb were reduced in almost all the cases giving good symptomatic relief. One out of the twenty cases had developed nausea and dyspepsia which was controlled with H2 Blockers and was relieved. Hence we conclude that Coumarin usage results in slow but safe reduction of lymphoedema in post mastectomy arm swelling and symptomatic relief.
[ABSTRACT]   Full text not available   
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Emperipolesis : an electron microscopic characteristic in rdd (rosai-dorfaman disease) : a case report
P Viswanathan, K Raghunathan, U Majhi, RV Pandit, G Shanthi, T Rajkumar
March 1997, 18(1):14-16
Emperipolesis is an ultrastructural phenomenon in which a viable cell is seen lying within another cell in a single membrane-bound vacuole. This is a constant finding in Sinus Histiocytosis with Massive Lymphadenopathy, otherwise known as Rosai-Dorfman Disease which is a rare clinicopathological entity. We are reporting here two cases of SHML diagnosed clinically and pathologically at Cancer Institute, Madras. In both the cases the phenomenon of emperipolesis was observed in lymph node biopsy samples at the ultrastructural level, wherein several lymphocytes are seen in the cytoplasm of the histiocytes within membrane-bound vacuoles.
[ABSTRACT]   Full text not available   
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Carcinoma of breast and sarcoma in a mother and child : a familial syndrome
R Arora, S Jain, R Vashistha, H Singh, A Chabbra, MD Oswal
March 1997, 18(1):19-21
Familial aggregation in certain malignant neoplasm is well known. We are presenting a report of young mothers with breast cancer, one whose son developed paraspinal fibrosarcoma and in the second family the daughter developed osteogenic sarcoma. The possibility of a familial syndrome-Li-Fraumeni syndrome is suggested with relevant review of literature.
[ABSTRACT]   Full text not available   
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Current status of chemotherapy in bone sarcomas
SR Patel, RS Benjamin
March 1997, 18(1):5-8
Primary bone sarcomas are rare tumours with an annual incidence of 2500 new cases in the USA. These tumours affect individuals of varying age groups and have a variable biology and prognosis depending on specific histologic characteristics. Many of these tumours that were universally lethal due to their extremely high metastatic potential are now curable with aggressive multimodality treatment including chemotherapy, surgery and radiation therapy.
[ABSTRACT]   Full text not available   
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Ondansetron in chemotherapy induced emesis
RI Dave
March 1997, 18(1):22-23
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Genetic Defects in cancer, what after screening?
RBV Nimmagadda
March 1997, 18(1):1-2
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Occult cns metastases of high risk gestational trophoblastic disease(gtd)
PS Dave, KS Dave, MH Mankad, AS Mehta, AS Kapadia
March 1997, 18(1):24-25
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UA Gandhi
March 1997, 18(1):26-28
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