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Indian Journal of Medical and Paediatric Oncology
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   1999| March  | Volume 20 | Issue 1  
    Online since May 30, 2009

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Vancomycin resistant enterococci.
MM Chandiwal, C Rodrigues, SV Almel, AP Mehta, Kapadia-AC
March 1999, 20(1):16-19
Enterococcal isolates today are increasingly resistant to antibiotics and are also becoming common nosocomial pathogens. This double evolution is associated with extensive use of oral cephalosporins, aminoglycosides and quinolones, which have poor in vitro activity against this bacterial genus. This gives the enterococci, an inherent advantage over others in being selected out. We report the first isolate of vancomycin resistant enterococci (VRE) at our centre. Though our patient had no morbidity associated with VRE, it is necessary to prevent dissemination with proper barrier precautions and policy. Since there is no fully efficient therapy for infections due to glycopeptide resistant enterococci, efforts to limit the spread of these microorganisms are now considered essential.
[ABSTRACT]   Full text not available   
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Lymphoma of the oral tongue
RV Nayyar, P Gupta, J Jojo, S Desai, U Tripathi, HK Shukla, RA Tankshali, RI Dave
March 1999, 20(1):22-25
Oral manifestations are present in about 3 to 5 percent of cases of non-Hodgkins lymphoma (NHL) and an oral tongue lesion is rarely the initial manifestation of NHL. Every year, at the Gujarat Cancer & Research Institute about 13,000 cases are registered with the head and neck cancer comprising of 2,300 cases. A case is presented of a 30 year old female patient with NHL of the oral tongue (anterior 2/3) without visceral or lymphnode involvement. the diagnosis of NHL, being suspicious on biopsy, was confirmed with cytologic and histopathological study following a wide excision of the tumour. The prognosis of NHL seems to be related to the tumour stage, tumour aggressiveness and its response to treatment. Rarity of the disease, successful management of the case and review of the literature are presented.
[ABSTRACT]   Full text not available   
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Interferon alpha-2B in patients of acute lymphoblastic leukemia afflicted with chronic hepatitis B : early observations.
KP Sajnani, AS Anand, PM Shah, SN Shukla, KM Patel, BJ Parikh, SS Talati, S Shah, BB Parekh, H Panchal, SV Nath, UB, Parekh
March 1999, 20(1):10-15
AIM: To investigate the efficacy and safely of interferon (IFN) therapy in patients with acute lymphatic leukaemia (ALL) with chronic hepatitis B (CHB). PATIENTS & METHODS: 22 patients of ALL, who were in complete remission after completion of the planned treatment and with HBsAG and HBeAg positive reports for more than 6 months, received IFN in 2 dose schedules (1) 3 miu subcutaneously (SC) daily for 4 weeks and 3 miu subcutaneously twice in a week for 12 weeks (2) 3 miu SC twice in a week for 16 weeks. Eighteen were males and 4 were females, aged from 7 years to 19 years (Median 13 years). Pretreatment serum alamine aminotransferase (ALT) was normal in 9 and elevated in 13. HBV DNA was positive in all patients. Median follow up was 13.6 months (range : 8 months to 36 months). RESULTS: Normalisation of ALT occured in 8 of 13 (61.5 percent) patients with elevated values before the administration of interferon. Mean time to achieve normalisation of ALT was 6.2 months after start of IFN. Eight of 22 patients (36 percent) became HBeAg negative and 2 of 6 patients, who were tested by HBV-DNA, became HBV-DNA negative after treatment. The only side effect observed was fever in 4 patients and it was managed with paracetamol. This study showed : (1) a good rate of biochemical and virologic response to IFN in patients of ALL with CHB. (2) Response to IFN was dependent on pretreatment ALT values. CONCLUSIONS: IFN is safe and effective in patients of ALL afflicted with CHB.
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Hodgkin's lymphoma in a patient with marfan's syndrome
N Geetha, TV Ajithkumar, VS Lali, S Chitra, MK. Nair
March 1999, 20(1):20-21
Full text not available   
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Amifostine in the treatment of cancer.
DN Sharma, PK Julka
March 1999, 20(1):7-9
Full text not available   
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Hepatitis B virus infections.
S Patwari
March 1999, 20(1):3-4
Full text not available   
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Issues related to primary and subsequent prevention of chromic infections with hepatitis B virus.
SN. Shukla
March 1999, 20(1):5-6
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