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Indian Journal of Medical and Paediatric Oncology
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   2000| September-December  | Volume 21 | Issue 3  
    Online since May 30, 2009

 
 
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Malignant phylloid tumour of the breast in a long term survivor of hodgkin's disease
TG Sagar, A Chandra, SG Raman, U Majhi
September-December 2000, 21(3):81-84
This short report documents a case of malignant phylloides tumour of the breast in a female patient of Hodgkin's disease, about 14 years after initial complete remission. It represents a rare case ever reported. Data about the clinical and pathological significance and treatment modalities are discussed.
[ABSTRACT]   Full text not available   
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Deciding about the appropriate chemotherapy regimen for gestational trophoblastic tumours
KS Dave, JD Prajapati, AS Kapadia, AD Desai, MH Mankad, SM Patel, PS Dave, RP Bansali, AS Chauhan
September-December 2000, 21(3):74-80
A retrospective analysis of 75 patients suffering from gestational trophoblastic tumours treated at the Gujarat Cancer Research Institute (GCRI), Amadavad, between 1995 and 1999 has been done. According to the WHO scoring system, 48 percent 21.3 percent and 30.7 percent of patients were of low risk (LR), medium risk (MRR) and high risk (G\HR) groups, respectively. Low risk (LR) patients were treated with methotrexate and folinic acid (MTX-FA) regimen. The medium risk (MR) patients received either MTX-FA or etoposide, methotrexate and actinomycin (EMA) and the high risk (HR) patients received EMA or EMA plus cyclophosphamide and vincristive (EMA-CO). Those with confirmed brain metastasis also received intrathecal methotrexate. All the patients (100 percent) with LR achieved remission with the most commonly used regimen MTX-FA. The MR group of patients also achieved 100 percent remission with MTX-FA,EMA, or EMA-CO regimen. Remission rate in the HR group was 61.1 percent (11/18) with the first line chemotherapy and additional 22.2 percent remission rate (4/18) was achieved with the second line chemotherapy (i.e. cisplatin and etoposide) making the total CR of 83.3 percent. Most commonly used regimen in HR group of patients was EMA-CO (10 as the first and 2 as the second line chemotherapy). Usefulness of EMA regimen in MR and HR groups of patients requires further study.
[ABSTRACT]   Full text not available   
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Retrospective five year follow up study of retinoblastoma : at Gujarat Cancer and Research Institute
N Shah, PM Shah, KM Patel, SN Shukla, BJ Parikh, A Anand, S Talati, S Shah, MV Vachharajani, B Parikh, B Tripathi, S Nath, H Panchal
September-December 2000, 21(3):69-73
Material: A retrospective study was undertaken to analyse the epidemiological and clinical aspects of retinoblastoma at the Gujarat Cancer and Research Institute, Amadavad, From June 1992 to December 1999 a total of 200 children with retinoblastoma were observed at GCRI, out of a total 3272 cases (6 percent) of paediatric cancers. Results: The present study reports the specific characteristics of retinoblastoma in the paediatric population of Gujarat and its neighbouring States, Only 77 (38.5 percent) patients were living in the Amadavad and nearby districts while the remaining had come from far off districts. There was male preponderance (65.5 percent). Thirteen percent of our patients had presented before the age of one and 89.5 percent were before their 5th birth date. The ration of unilateral to bilateral disease was 2.6:1. In 64 cases (32 percent) symptoms were present for more than 6 months. The most common presenting symptom was orbital mass. All eyes underwent fundoscopic examination and the staging work up was done. Majority of our patients had advanced disease(Stage III, 37.5 percent, Stage IV, 35 percent). Patients were treated with the help of surgery, chemotherapy, radiotherapy and photocoagulation according to their stage. One hundred and forty three cases (71.5 percent) were lost to follow up. In the final outcome 9 cases (15.7 percent) expired on treatment, 10 cases (17.5 percent) relapsed, 20 cases (25 percent) are taking treatment and 18 cases (31.5 percent) are in remission. Conclusion: Delay in diagnosis, extraocular disease at the time of presentation, lack of awareness and low socioeconomic and educational conditions may be the major factors for the high rate of failure and high drop out rate. There is a need to detect early intraocular disease and a campaign to increase general awareness.
[ABSTRACT]   Full text not available   
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Granulocytic sarcoma of rectum
MM Chandiwal, KS Jhaveri, SV Almel, MM Kapadia Shroff
September-December 2000, 21(3):85-87
Granulocytic sarcoma is an extramedullary tumour composed of immature granulocytic precusor cells. It usually occurs in association with leukaemia or other myeloproliferative disorders but can occur without overt haematological malignancy. We describe a case of granulocytic sarcoma of the rectum in a 63-year-old lady who presented with difficulty in defaecation and micturation. There was no overt leukaemia associated with the presentation. The case has been presented in view of its rarity and discussed in light of available literature.
[ABSTRACT]   Full text not available   
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Isotretioin-13-CIS-retinoic acid
SV Nath
September-December 2000, 21(3):88-95
Full text not available   
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Retinoblastoma
BJ Parikh
September-December 2000, 21(3):62-68
Full text not available   
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Ideals versus realities
SN Shukla
September-December 2000, 21(3):59-61
Full text not available   
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