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Concurrent Hairy Cell Leukemia and Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(04): 624
DOI: DOI: 10.4103/ijmpo.ijmpo_136_19
Sir,
Our patient who had concurrent chronic lymphocytic leukemia and hairy cell leukemia, viral serological markers including HIV and hepatitis viruses B and C were tested by the highly sensitive chemiluminescent immunoassay method. With this screening immunoassay, although false positivity can occur, the probability of false negativity is extremely low. This patient tested negative for all the three viruses. He was a previously fit and well gentleman and in light of the above negative tests, we did not think it prudent to further pursue CD4 counts and viral load estimation by polymerase chain reaction. These details could not be incorporated in the original case report due to word limit restrictions. However, the point raised of HIV predisposing to multiple lympho-proliferative malignancies is well taken.
Publication History
Received: 07 June 2019
Accepted: 19 September 2019
Article published online:
17 May 2021
© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
Sir,
Our patient who had concurrent chronic lymphocytic leukemia and hairy cell leukemia, viral serological markers including HIV and hepatitis viruses B and C were tested by the highly sensitive chemiluminescent immunoassay method. With this screening immunoassay, although false positivity can occur, the probability of false negativity is extremely low. This patient tested negative for all the three viruses. He was a previously fit and well gentleman and in light of the above negative tests, we did not think it prudent to further pursue CD4 counts and viral load estimation by polymerase chain reaction. These details could not be incorporated in the original case report due to word limit restrictions. However, the point raised of HIV predisposing to multiple lympho-proliferative malignancies is well taken.
Conflict of Interest
There are no conflicts of interest.
Address for correspondence
Publication History
Received: 07 June 2019
Accepted: 19 September 2019
Article published online:
17 May 2021
© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India