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Bilateral Tubular Adenoma-Breast, A Case Report

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2022; 43(S 01): S1-S19

DOI: DOI: 10.1055/s-0042-1755524

Correspondence to: sagarmhetre@rediffmail.com

Background: Fibroadenoma is one of the most common benign neoplasm of breast in a young female; however, tubular adenoma is a much rare benign breast neoplasm occurring in young women. These are clinically indistinguishable from other benign breast neoplasms and can be diagnosed only on the basis of histopathological examination.

Materials and Methods (Clinical Presentation): A 20-years old female presented to our hospital with complaints of lump in both breasts. On clinical examination, lumps were felt in upper-outer quadrants of both breasts below the nipple and areola. USG findings were suggestive of bilateral fibroadenoma of the breast. Patient underwent lump excision under the same provisional diagnosis of bilateral fibroadenoma. Resected lumps were sent to our department for histopathological examination.

Results (Histopathological Evaluation): Grossly, the mass consisted of multiple irregular tissue bits which were pinkish white in color. Microscopic examination of H&E-stained sections revealed tightly packed proliferated tubules lined by cuboidal epithelium having normochromatic nuclei and scanty intervening stroma. Hence from the histopathological examination the final diagnosis was established as bilateral tubular adenoma-breast, in a 20-year-old female.

Conclusion (and Why this Case Was Chosen): Tubular adenoma is a rare benign epithelial neoplasm of breast seen in young females, and it cannot be diagnosed on the basis of clinical, cytological, or radiological examination and is often labelled as fibroadenoma. Histopathology remains the gold-standard method to diagnose this entity which is only seen in handful of cases and bilateral involvement being even rare.



Publication History

Article published online:
22 August 2022

© 2022. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

  1. Multiple papillary adenomas (PA) coexisting with clear cell renal cell carcinoma (CCRCC):a case report
    HU Xiao-mu et al., Fudan University Journal of Medical Sciences, 2019
  2. Simultaneous bilateral distinct parotid tumors: a case report
    Zhang Bowen et al., West China Journal of Stomatology, 2021
  3. Renal Oncocytoma: Angiographic Features of Two Cases
    Shelley N. Weiner et al., Radiology, 1977
  4. X-ray Treatment in Gynecomastia
    John G. Menville et al., Radiology, 1932
  5. Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment
    Yang Hao et al., Molecular Biomedicine, 2022

Correspondence to: sagarmhetre@rediffmail.com

Background: Fibroadenoma is one of the most common benign neoplasm of breast in a young female; however, tubular adenoma is a much rare benign breast neoplasm occurring in young women. These are clinically indistinguishable from other benign breast neoplasms and can be diagnosed only on the basis of histopathological examination.

Materials and Methods (Clinical Presentation): A 20-years old female presented to our hospital with complaints of lump in both breasts. On clinical examination, lumps were felt in upper-outer quadrants of both breasts below the nipple and areola. USG findings were suggestive of bilateral fibroadenoma of the breast. Patient underwent lump excision under the same provisional diagnosis of bilateral fibroadenoma. Resected lumps were sent to our department for histopathological examination.

Results (Histopathological Evaluation): Grossly, the mass consisted of multiple irregular tissue bits which were pinkish white in color. Microscopic examination of H&E-stained sections revealed tightly packed proliferated tubules lined by cuboidal epithelium having normochromatic nuclei and scanty intervening stroma. Hence from the histopathological examination the final diagnosis was established as bilateral tubular adenoma-breast, in a 20-year-old female.

Conclusion (and Why this Case Was Chosen): Tubular adenoma is a rare benign epithelial neoplasm of breast seen in young females, and it cannot be diagnosed on the basis of clinical, cytological, or radiological examination and is often labelled as fibroadenoma. Histopathology remains the gold-standard method to diagnose this entity which is only seen in handful of cases and bilateral involvement being even rare.

No conflict of interest has been declared by the author(s).

Publication History

Article published online:
22 August 2022

© 2022. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

  1. Simultaneous bilateral distinct parotid tumors: a case report
    Zhang Bowen et al., West China Journal of Stomatology, 2021
  2. Renal Oncocytoma: Angiographic Features of Two Cases
    Shelley N. Weiner et al., Radiology, 1977
  3. Multiple papillary adenomas (PA) coexisting with clear cell renal cell carcinoma (CCRCC):a case report
    HU Xiao-mu et al., Fudan University Journal of Medical Sciences, 2019
  4. C(− 106)T polymorphism in ALR2 and risk of microvascular complications in T2DM patients in north Indian population
    Archana Mishra et al., Molecular Biomedicine, 2022
  5. X-ray Treatment in Gynecomastia
    John G. Menville et al., Radiology, 1932